{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:50:44Z","timestamp":1792464644872,"version":"4.5.0"},"reference-count":112,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    Possession of the apolipoprotein E4 (APOE4) allele and diabetes risk are independently related to reduced white matter (WM) integrity that may contribute to the development of Alzheimer\u2019s disease (AD). The purpose of this study is to examine the interactive effects of APOE4 and diabetes risk on later myelinating WM regions among healthy elderly individuals at risk of AD. A sample of 107 healthy elderly (80 APOE4\u2212\/27 APOE4+) individuals underwent structural magnetic resonance imaging\/diffusion tensor imaging (DTI). Data were prepared using Tract-Based Spatial Statistics, and a priori regions of interest (ROIs) were extracted from T1-based WM parcellations. Regions of interest included later myelinating frontal\/temporal\/parietal WM regions and control regions measured by fractional anisotropy (FA). There were no APOE group differences in DTI for any ROI. Within the APOE4 group, we found negative relationships between hemoglobin A\n                    <jats:sub>1c<\/jats:sub>\n                    \/fasting glucose and APOE4 on FA for all later myelinating WM regions but not for early\/middle myelinating control regions. Results also showed APOE4\/diabetes risk interactions for WM underlying supramarginal, superior temporal, precuneus, superior parietal, and superior frontal regions. Results suggest interactive effects of APOE4 and diabetes risk on later myelinating WM regions, which supports preclinical detection of AD among this particularly susceptible subgroup.\n                  <\/jats:p>","DOI":"10.1177\/1533317513517045","type":"journal-article","created":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T20:16:14Z","timestamp":1388520974000},"page":"222-235","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Interactive Effects of Apolipoprotein E4 and Diabetes Risk on Later Myelinating White Matter Regions in Neurologically Healthy Older Aged Adults"],"prefix":"10.1177","volume":"29","author":[{"given":"Jessica M.","family":"Foley","sequence":"first","affiliation":[{"name":"Psychology Service, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Salat","sequence":"additional","affiliation":[{"name":"Psychology Service, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki H.","family":"Stricker","sequence":"additional","affiliation":[{"name":"Psychology Service, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler A.","family":"Zink","sequence":"additional","affiliation":[{"name":"Psychology Service, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Grande","sequence":"additional","affiliation":[{"name":"Psychology Service, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina E.","family":"McGlinchey","sequence":"additional","affiliation":[{"name":"Psychology Service, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Milberg","sequence":"additional","affiliation":[{"name":"Psychology Service, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Leritz","sequence":"additional","affiliation":[{"name":"Psychology Service, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Division of Aging, Brigham & Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,12,31]]},"reference":[{"key":"bibr1-1533317513517045","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2009.11.2\/cqiu"},{"key":"bibr2-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-9070-1"},{"key":"bibr3-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1159\/000113698"},{"key":"bibr4-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.993"},{"key":"bibr5-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.4.985"},{"key":"bibr6-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.139"},{"key":"bibr7-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1031789"},{"key":"bibr8-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"bibr9-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1159\/000109150"},{"key":"bibr10-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440226"},{"key":"bibr11-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00217-2"},{"key":"bibr12-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.043"},{"key":"bibr13-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-002-0142-8"},{"key":"bibr14-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1996.tb02377.x"},{"key":"bibr15-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00743-X"},{"key":"bibr16-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(99)00107-4"},{"key":"bibr17-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.039"},{"key":"bibr18-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000125859.71051.83"},{"key":"bibr19-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00779.x"},{"key":"bibr20-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00361-1"},{"key":"bibr21-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000033200.58646.B3"},{"key":"bibr22-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000174058.49521.16"},{"key":"bibr23-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64788-8"},{"key":"bibr24-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01436.x"},{"key":"bibr25-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.07.001"},{"key":"bibr26-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.08.058"},{"key":"bibr27-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1037\/a0018108"},{"key":"bibr28-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.050"},{"key":"bibr29-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.07.033"},{"key":"bibr30-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22030"},{"key":"bibr31-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.217117"},{"key":"bibr32-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.11.1551"},{"key":"bibr33-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.29"},{"key":"bibr34-1533317513517045","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1256"},{"key":"bibr35-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318211c3ae"},{"key":"bibr36-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181eee25f"},{"key":"bibr37-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00087-2"},{"key":"bibr38-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06371.x"},{"key":"bibr39-1533317513517045","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2002-4606"},{"key":"bibr40-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.12.1870"},{"key":"bibr41-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02355-7"},{"key":"bibr42-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.07.009"},{"key":"bibr43-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.9.2182"},{"key":"bibr44-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2003.00456.x"},{"key":"bibr45-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.03.001"},{"key":"bibr46-1533317513517045","first-page":"417","volume-title":"New Encyclopedia of Neuroscience","author":"Bartzokis G","year":"2007"},{"key":"bibr47-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.1.63"},{"key":"bibr48-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.03.024"},{"key":"bibr49-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.01.019"},{"key":"bibr50-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.06.001"},{"key":"bibr51-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.041"},{"key":"bibr52-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014170"},{"key":"bibr53-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.04.016"},{"key":"bibr54-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940080707"},{"key":"bibr55-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.063016"},{"key":"bibr56-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0455.43.s.428.1.x"},{"key":"bibr57-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21572"},{"key":"bibr58-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2009.03.014"},{"key":"bibr59-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-008-0286-1"},{"key":"bibr60-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1340.009"},{"key":"bibr61-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.03.013"},{"key":"bibr62-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2009.11.003"},{"key":"bibr63-1533317513517045","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1163"},{"key":"bibr64-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2012.10.003"},{"key":"bibr65-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj036"},{"key":"bibr66-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.072"},{"key":"bibr67-1533317513517045","author":"Leritz EC","year":"2013","journal-title":"Hum Brain Mapp"},{"key":"bibr68-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.43.5.377"},{"key":"bibr69-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90082-5"},{"key":"bibr70-1533317513517045","unstructured":"American Diabetes Association. 2009."},{"key":"bibr71-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10308"},{"key":"bibr72-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"bibr73-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"bibr74-1533317513517045","unstructured":"Andersson JLR, Jenkinson M, Smith S. Non-linear optimisation. FMRIB technical report TR07JA1 from www.fmrib.ox.ac.uk\/analysis\/techrep. 2007 Accessed March 2013."},{"key":"bibr75-1533317513517045","unstructured":"Andersson JLR, Jenkinson M, Smith S. Non-linear registration, aka spatial normalisation FMRIB technical report TR07JA2 from www.fmrib.ox.ac.uk\/analysis\/techrep. 2007 Accessed March 2013."},{"key":"bibr76-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1109\/42.796284"},{"key":"bibr77-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.030"},{"key":"bibr78-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"bibr79-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.06.060"},{"key":"bibr80-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"bibr81-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.02.023"},{"key":"bibr82-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.094"},{"key":"bibr83-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-1154-2"},{"key":"bibr84-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.02.038"},{"key":"bibr85-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.12.1930"},{"key":"bibr86-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.7.635"},{"key":"bibr87-1533317513517045","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-3-200208060-00006"},{"key":"bibr88-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.913"},{"key":"bibr89-1533317513517045","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0555"},{"key":"bibr90-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0688-y"},{"key":"bibr91-1533317513517045","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.04.06.db05-1323"},{"key":"bibr92-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1163"},{"key":"bibr93-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31822e0831"},{"key":"bibr94-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.04.025"},{"key":"bibr95-1533317513517045","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2052"},{"key":"bibr96-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1857-y"},{"key":"bibr97-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.052"},{"key":"bibr98-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.08.017"},{"key":"bibr99-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00434-2"},{"key":"bibr100-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/609202"},{"key":"bibr101-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2008.05.011"},{"key":"bibr102-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.1.70"},{"key":"bibr103-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.05.016"},{"key":"bibr104-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.225532"},{"key":"bibr105-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318185e7fe"},{"key":"bibr106-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.252"},{"key":"bibr107-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.8.1053"},{"key":"bibr108-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.02.003"},{"key":"bibr109-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.5.501"},{"key":"bibr110-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1461"},{"key":"bibr111-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10093"},{"key":"bibr112-1533317513517045","doi-asserted-by":"publisher","DOI":"10.1159\/000051267"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317513517045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533317513517045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317513517045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:19:50Z","timestamp":1777367990000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317513517045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,31]]},"references-count":112,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1177\/1533317513517045"],"URL":"https:\/\/doi.org\/10.1177\/1533317513517045","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,31]]}}}