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Reports detailing reduced brain glucose metabolism in the early stages of AD led to the hypothesis that alternate energy sources aimed at increasing neuronal metabolism may protect neurons and thus benefit patients with AD. Medium-chain triglycerides (MCTs) are metabolized to ketone bodies that serve as an alternative source of energy for neurons. Data from clinical trials suggest that MCTs improve cognition in patients with mild to moderate AD in apolipoprotein E4\u2013negative patients. Adverse events observed were mild and included minor gastrointestinal problems such as diarrhea, dyspepsia, and flatulence. However, since genomic profiles are not routinely conducted in patients with AD in a clinical setting, the role of MCTs in clinical practice seems to be minimal.<\/jats:p>","DOI":"10.1177\/1533317513518650","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T21:04:43Z","timestamp":1389387883000},"page":"409-414","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Role of Medium Chain Triglycerides (Axona\n                    <sup>\u00ae<\/sup>\n                    ) in the Treatment of Mild to Moderate Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"29","author":[{"given":"Alok","family":"Sharma","sequence":"first","affiliation":[{"name":"MCPHS University, Manchester, NH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bemis","sequence":"additional","affiliation":[{"name":"MCPHS University, Manchester, NH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia R.","family":"Desilets","sequence":"additional","affiliation":[{"name":"Concord Hospital, Concord, NH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,9]]},"reference":[{"key":"bibr1-1533317513518650","unstructured":"The Alzheimer's Association. http:\/\/www.alz.org\/. 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