{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:58:12Z","timestamp":1777381092316,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:00:00Z","timestamp":1400198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>\n                    Amyloid \u03b2\n                    <jats:sub>25-35<\/jats:sub>\n                    (A\u03b2\n                    <jats:sub>25-35<\/jats:sub>\n                    ) represents a neurotoxic fragment of A\u03b2\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sub>-<\/jats:sub>\n                    <jats:sub>40<\/jats:sub>\n                    or A\u03b2\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sub>-<\/jats:sub>\n                    <jats:sub>42<\/jats:sub>\n                    , and is implicated in the progressive neurodegeneration in cases of the Alzheimer disease (AD). Amyloid \u03b2\n                    <jats:sub>25-35<\/jats:sub>\n                    was shown to lyse rat erythrocytes (RBCs) of all ages, and the extent of the RBC toxicity is directly correlated with A\u03b2\n                    <jats:sub>25-35<\/jats:sub>\n                    concentration and cell age. Activities of glycolytic, antioxidant, and Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    -adenosine triphosphatase (ATPase) enzymes, in vivo, are significantly decreased in older RBCs as compared to the young RBCs. In vitro, A\u03b2\n                    <jats:sub>25-35<\/jats:sub>\n                    reduced activities of hexokinase, phosphofructokinase, pyruvate kinase, glutathione peroxidase, and glutathione transferase and increased Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase activity; these effects are significantly greater in aged RBCs as compared to those of the younger cells. The diminution in activity of certain enzymes may determine the life span of the RBCs in vivo and may be relevant to the human AD; higher sensitivity of older RBCs to A\u03b2\n                    <jats:sub>25-35<\/jats:sub>\n                    toxicity may contribute to the ultimate death of the RBCs in patients with AD.\n                  <\/jats:p>","DOI":"10.1177\/1533317514534757","type":"journal-article","created":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T01:40:25Z","timestamp":1400290825000},"page":"685-695","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of Amyloid \u03b2\n                    <sub>25-35<\/sub>\n                    on Membrane Stability, Energy Metabolism, and Antioxidant Enzymes in Erythrocytes"],"prefix":"10.1177","volume":"29","author":[{"given":"Lyudmila A.","family":"Tikhonova","sequence":"first","affiliation":[{"name":"Pushchino State Institute of Natural Sciences, Pushchino, Russia"},{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yury G.","family":"Kaminsky","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Prakash","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Missouri University of Science and Technology, Rolla, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Human Sciences, Texas A&M University-Kingsville, Kingsville, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya N.","family":"Solomadin","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena A.","family":"Kosenko","sequence":"additional","affiliation":[{"name":"Pushchino State Institute of Natural Sciences, Pushchino, Russia"},{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gjumrakch","family":"Aliev","sequence":"additional","affiliation":[{"name":"School of Health Science and Healthcare Administration, University of Atlanta, Johns Creek, GA, USA"},{"name":"GALLY International Biomedical Research Consulting LLC, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"bibr1-1533317514534757","volume-title":"Alzheimer Disease","author":"Robakis NK"},{"key":"bibr2-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439760"},{"key":"bibr3-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1038\/359322a0"},{"key":"bibr4-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1038\/361260a0"},{"key":"bibr5-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200406068"},{"key":"bibr6-1533317514534757","volume-title":"The Role of Oxidative Stress, Mitochondria Failure, and Cellular Hypoperfusion in the Context of Alzheimer Disease: Past, Present and Future","author":"Aliev G","year":"2013"},{"key":"bibr7-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.11.004"},{"key":"bibr8-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64010253.x"},{"key":"bibr9-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.09.005"},{"key":"bibr10-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00824-X"},{"issue":"5","key":"bibr11-1533317514534757","first-page":"654","volume":"34","author":"Kosenko EA","year":"2008","journal-title":"Bioorg Khim"},{"issue":"4","key":"bibr12-1533317514534757","first-page":"507","author":"Solomadin IN","year":"2008","journal-title":"Izv Akad Nauk Ser Biol"},{"issue":"1","key":"bibr13-1533317514534757","first-page":"123","volume":"80","author":"Lurie S","year":"1992","journal-title":"Obstet Gynecol"},{"key":"bibr14-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(87)90049-2"},{"key":"bibr15-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830080105"},{"key":"bibr16-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(93)90121-K"},{"key":"bibr17-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014559331402"},{"key":"bibr18-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6417-10.2011"},{"key":"bibr19-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.08.013"},{"key":"bibr20-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb00589.x"},{"key":"bibr21-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(92)90120-J"},{"key":"bibr22a-1533317514534757","volume-title":"Red Cell Metabolism","author":"Beutler E","year":"1986"},{"key":"bibr22b-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"bibr23-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-76698-8_22"},{"issue":"2","key":"bibr24-1533317514534757","first-page":"172","volume":"35","author":"Kosenko EA","year":"2009","journal-title":"Bioorg Khim"},{"key":"bibr25-1533317514534757","doi-asserted-by":"publisher","DOI":"10.3109\/10715769709097867"},{"key":"bibr26-1533317514534757","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01723.x"},{"key":"bibr27-1533317514534757","unstructured":"BunnHF.Approach to the anemias. 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