{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:51:54Z","timestamp":1778835114482,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>The loss of cholinergic transmission is considered to be an important cause of Alzheimer\u2019s disease (AD). Treatment with acetyl cholinesterase inhibitors (ChEIs) shows benefits; however, great heterogeneity has been observed in patient responses. We evaluated apolipoprotein E ( APOE) and \u03b17 nicotinic receptor ( CHRNA7) single-nucleotide polymorphisms (SNPs) and associated these SNPs with pharmacological responses to ChEIs in a Brazilian population with AD. We studied 177 outpatients using ChEIs, and they were classified as responders and nonresponders according to variation in Mini-Mental State Examination (MMSE) status. The analysis of APOE genotypes showed that patients with the \u220a4 allele had a worse response than those without the \u220a4 allele. We observed an association between the CHRNA7 T allele and a better response to treatment with ChEIs in patients with mild AD (MMSE \u2265 20). The SNP rs6494223 of CHRNA7 as well as APOE\u220a4 could be useful for understanding the response to ChEI treatment in patients with AD.<\/jats:p>","DOI":"10.1177\/1533317514539540","type":"journal-article","created":{"date-parts":[[2014,6,21]],"date-time":"2014-06-21T00:45:33Z","timestamp":1403311533000},"page":"139-144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Effect of\n                    <i>APOE<\/i>\n                    and\n                    <i>CHRNA7<\/i>\n                    Genotypes on the Cognitive Response to Cholinesterase Inhibitor Treatment at Different Stages of Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"30","author":[{"given":"Ianna Lacerda Sampaio","family":"Braga","sequence":"first","affiliation":[{"name":"Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo-SP, 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