{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:51:23Z","timestamp":1792050683010,"version":"4.4.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To investigate the patterns of inheritance and gene mutation status in early-onset dementia (EOD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data were collected on 202 consecutive patients presenting to an EOD clinic. Early-onset Alzheimer\u2019s disease (EOAD, n = 120) and early-onset frontotemporal dementia (EOFTD, n = 82) were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The majority of participants, 72.5% with EOAD and 74.4% with EOFTD, did not have a positive family history of dementia. An autosomal dominant pattern of inheritance was observed in 14.2% of patients with EOAD and 13.4% of patients with FTD. Of those with an autosomal dominant pattern of inheritance, 11.8% of EOAD and 45.5% of FTD probands had known pathogenic mutations. Only 1.6% of the total population of EOAD and 7.3% of EOFTD possessed known gene mutations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early-onset dementia does not appear to be a strongly inherited autosomal dominant condition. The majority of patients were sporadic. Known mutations were uncommon and do not explain the total autosomal dominant burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533317514545825","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T02:16:49Z","timestamp":1408673809000},"page":"299-306","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":80,"title":["The Patterns of Inheritance in Early-Onset Dementia"],"prefix":"10.1177","volume":"30","author":[{"given":"Anna I.","family":"Jarmolowicz","sequence":"first","affiliation":[{"name":"Neurodegenerative Disorders Research Pty Ltd, Subiaco, West Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huei-Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disorders Research Pty Ltd, Subiaco, West Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Panegyres","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disorders Research Pty Ltd, Subiaco, West Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"bibr1-1533317514545825","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.9.1206"},{"key":"bibr2-1533317514545825","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67889-0"},{"key":"bibr3-1533317514545825","doi-asserted-by":"publisher","DOI":"10.2190\/Q6J4-R143-P630-KW41"},{"key":"bibr4-1533317514545825","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1215"},{"key":"bibr5-1533317514545825","doi-asserted-by":"publisher","DOI":"10.1177\/1533317512459798"},{"key":"bibr6-1533317514545825","doi-asserted-by":"publisher","DOI":"10.1177\/1533317506295887"},{"key":"bibr7-1533317514545825","volume-title":"Young Onset Dementia: Epidemiology, Clinical Symptoms, Family Burden, Support and 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