{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:42:57Z","timestamp":1788316977856,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Rationale:<\/jats:title>\n                    <jats:p>Adherence to cholinesterase inhibitor (ChEI) is associated with treatment effectiveness in the treatment of Alzheimer\u2019s disease (AD). We investigated the clinical adherence to donepezil in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective study. Patients treated with donepezil were recruited from Kaohsiung Medical University Hospital and Kaohsiung Municipal Ta-Tung Hospital from February 2004 to April 2013. We analyzed their treatment duration in months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 273 patients were included in our analysis. Sixty-seven patients withdrew from donepezil treatment with mean treatment duration of 28.0 \u00b1 25.9 months. Better initial scores on the Mini-Mental Status Examination ( P = .007), Cognitive Abilities Screening Instrument ( P = .003), and the Clinical Dementia Rating Scale (CDR) Sum of Boxes ( P = .011) were positively associated with clinical adherence. The clinical adherent rate was higher in the CDR-0.5 group than in the CDR-2.0 group with significant difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although there are some limitations in our study, these findings indicate that early intervention with ChEI in patients with AD should be emphasized and may lead to a better clinical adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533317514556875","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:47:00Z","timestamp":1415407620000},"page":"346-351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Compliance of Donepezil in Treating Alzheimer\u2019s Disease in Taiwan"],"prefix":"10.1177","volume":"30","author":[{"given":"Yun-Ping","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu-Hsien","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan"},{"name":"Division of Community Medicine, Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Chuan","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Han","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan"},{"name":"Department of and Master\u2019s Program in Neurology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"bibr1-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066252"},{"key":"bibr2-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1946"},{"key":"bibr3-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.3.489"},{"key":"bibr4-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.3.481"},{"key":"bibr5-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16499-4"},{"key":"bibr6-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1159\/000345279"},{"key":"bibr7-1533317514556875","doi-asserted-by":"publisher","DOI":"10.2174\/157015910790909520"},{"issue":"1","key":"bibr8-1533317514556875","first-page":"CD001190","author":"Birks J","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr9-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.1.136"},{"key":"bibr10-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X233403"},{"key":"bibr11-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1159\/000114450"},{"key":"bibr12-1533317514556875","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200923040-00003"},{"key":"bibr13-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1159\/000347140"},{"key":"bibr14-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2008.00875.x"},{"key":"bibr15-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.12.1852"},{"key":"bibr16-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"bibr17-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"bibr18-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1159\/000066024"},{"key":"bibr19-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"bibr20-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.8.1091"},{"key":"bibr21-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.02049.x"},{"key":"bibr22-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2002.tb11294.x"},{"issue":"4","key":"bibr23-1533317514556875","doi-asserted-by":"crossref","first-page":"312","DOI":"10.33588\/rn.3904.2004292","volume":"39","author":"Sicras A","year":"2004","journal-title":"Rev Neurol"},{"key":"bibr24-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X56565"},{"key":"bibr25-1533317514556875","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2005.11.3.231"},{"key":"bibr26-1533317514556875","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522080-00006"},{"key":"bibr27-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.493788"},{"key":"bibr28-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902234"},{"issue":"5","key":"bibr29-1533317514556875","doi-asserted-by":"crossref","first-page":"421","DOI":"10.33588\/rn.3605.2002416","volume":"36","author":"Turon-Estrada A","year":"2003","journal-title":"Rev Neurol"},{"key":"bibr30-1533317514556875","doi-asserted-by":"publisher","DOI":"10.1177\/1533317513504818"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317514556875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533317514556875","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317514556875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:05Z","timestamp":1777368005000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317514556875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,7]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1177\/1533317514556875"],"URL":"https:\/\/doi.org\/10.1177\/1533317514556875","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,7]]}}}