{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:59:24Z","timestamp":1777381164133,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Blood\u2013brain barrier impairment and endothelial cell dysfunction have both been implicated in the pathogenesis of Alzheimer\u2019s disease (AD). The presence of vascular risk factors is also known to increase the risk of AD. Soluble endothelial protein C receptor (sEPCR) should thus produce procoagulant and proinflammatory effects. Serum sEPCR levels have been found to be associated with several diseases. To date, no reports have been published regarding serum sEPCR levels in AD. In this study, we found that serum sEPCR levels were significantly increased in patients with AD when compared to control participants ( P = .0005). There was no significant difference between patients with mild cognitive impairment (MCI) and healthy controls ( P = .055) or between patients with AD and MCI ( P = .054). Importantly, our results also indicate that the degree of cognitive impairment is significantly correlated with serum sEPCR levels in all patients and healthy controls. These findings suggest that serum sEPCR levels could be a potential candidate for a biomarker panel for AD diagnosis.<\/jats:p>","DOI":"10.1177\/1533317514567124","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:34:03Z","timestamp":1421282043000},"page":"517-521","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum sEPCR Levels Are Elevated in Patients With Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"30","author":[{"given":"Yongjian","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhilong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xugang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the People's Hospital of Daye City, Daye, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"bibr1-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000014421.15948.67"},{"key":"bibr2-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.02.001"},{"key":"bibr3-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000095973.42032.44"},{"key":"bibr4-1533317514567124","first-page":"324016","volume":"2012","author":"Schreitm\u00fcller B","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"bibr5-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0284-6"},{"key":"bibr6-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613883"},{"key":"bibr7-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100017200"},{"key":"bibr8-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-003004"},{"key":"bibr9-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119548"},{"key":"bibr10-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.8.6038"},{"key":"bibr11-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.29.17499"},{"key":"bibr12-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.8.5447"},{"key":"bibr13-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.07.023"},{"key":"bibr14-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"bibr15-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"bibr16-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"bibr17-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119548"},{"key":"bibr18-1533317514567124","doi-asserted-by":"crossref","unstructured":"Bilgic MA, Yilmaz H, Bozkurt A, Relationship of late arteriovenous fistula stenosis with soluble E-selectin and soluble EPCR in chronic hemodialysis patients with arteriovenous fistula[published online March 14, 2014]. Clin Exp Nephrol. 2014.","DOI":"10.1007\/s10157-014-0955-4"},{"key":"bibr19-1533317514567124","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2012.1492"},{"key":"bibr20-1533317514567124","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-11106"},{"key":"bibr21-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6743"},{"key":"bibr22-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"bibr23-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0522-3"},{"key":"bibr24-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0245-7"},{"key":"bibr25-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.05.014"},{"key":"bibr26-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3114"},{"key":"bibr27-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.2.725"},{"key":"bibr28-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1177\/0891988704269822"},{"key":"bibr29-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200207000-00004"},{"key":"bibr30-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1016\/1050-1738(95)00054-D"},{"key":"bibr31-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.02.321"},{"key":"bibr32-1533317514567124","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.117"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317514567124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533317514567124","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317514567124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:06Z","timestamp":1777368006000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317514567124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,14]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1177\/1533317514567124"],"URL":"https:\/\/doi.org\/10.1177\/1533317514567124","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,14]]}}}