{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:54:07Z","timestamp":1792173247930,"version":"4.4.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Brain tissue analysis is necessary to confirm prion diseases. Clinically unsuspected cases may be identified through neuropathologic testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>National Alzheimer\u2019s Coordinating Center (NACC) Minimum and Neuropathologic Data Set for 1984 to 2005 were reviewed. Eligible patients had dementia, underwent autopsy, had available neuropathologic data, belonged to a currently funded Alzheimer\u2019s Disease Center (ADC), and were coded as having an Alzheimer\u2019s disease clinical diagnosis or a nonprion disease etiology. For the eligible patients with neuropathology indicating prion disease, further clinical information, collected from the reporting ADC, determined whether prion disease was considered before autopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 6000 eligible patients in the NACC database, 7 (0.12%) were clinically unsuspected but autopsy-confirmed prion disease cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The proportion of patients with dementia with clinically unrecognized but autopsy-confirmed prion disease was small. Besides confirming clinically suspected cases, neuropathology is useful to identify unsuspected clinically atypical cases of prion disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533317515602218","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T19:57:55Z","timestamp":1440791875000},"page":"752-755","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinically Unsuspected Prion Disease Among Patients With Dementia Diagnoses in an Alzheimer\u2019s Disease Database"],"prefix":"10.1177","volume":"30","author":[{"given":"Ryan A.","family":"Maddox","sequence":"first","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Blase","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. D.","family":"Mercaldo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University, Nashville, TN, USA"},{"name":"National Alzheimer\u2019s Coordinating Center, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. B.","family":"Schonberger","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. A.","family":"Kukull","sequence":"additional","affiliation":[{"name":"National Alzheimer\u2019s Coordinating Center, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. D.","family":"Belay","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,8,27]]},"reference":[{"key":"bibr1-1533317515602218","doi-asserted-by":"publisher","DOI":"10.1086\/432726"},{"key":"bibr2-1533317515602218","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000036913.87823.D6"},{"key":"bibr3-1533317515602218","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.534"},{"issue":"4","key":"bibr4-1533317515602218","first-page":"270","volume":"18","author":"Beekly DL","year":"2004","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"bibr5-1533317515602218","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.3.727"},{"key":"bibr6-1533317515602218","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22454"},{"key":"bibr7-1533317515602218","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-198903010-00009"},{"key":"bibr8-1533317515602218","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.1.33"},{"key":"bibr9-1533317515602218","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.12.2345"},{"key":"bibr10-1533317515602218","unstructured":"National Prion Disease Pathology Surveillance Center. http:\/\/www.cjdsurveillance.com\/. Accessed August 14, 2015."}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317515602218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533317515602218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317515602218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:12Z","timestamp":1777368012000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317515602218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,27]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1177\/1533317515602218"],"URL":"https:\/\/doi.org\/10.1177\/1533317515602218","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,27]]}}}