{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:32:55Z","timestamp":1789785175399,"version":"4.0.1"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>The interest in poor magnesium (Mg) status as risk factor for Alzheimer\u2019s disease (AD) is increasing due to its antioxidant and neuroprotective properties. A systematic PubMed literature search of studies investigating Mg status was undertaken comparing AD to healthy controls (HCs) or patients with medical illness (medical controls [MCs]). Standardized mean differences (SMDs) \u00b1 95% confidence intervals (CIs) were calculated for all outcomes. Of 192 potentially eligible studies, 13 were included (559 patients with AD, 381 HCs, and 126 MCs). Compared to HCs, patients with AD had significantly lower Mg in cerebrospinal fluid (2 studies; SMD = \u22120.35; P = .02) and in hair (2 studies; SMD = \u22120.75; P = .0001). No differences between AD and controls were evident for serum Mg. In conclusion, AD seems to be associated with a lower Mg status when compared to HCs, while the scarcity of studies limited the findings about MCs.<\/jats:p>","DOI":"10.1177\/1533317515602674","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T19:59:10Z","timestamp":1441742350000},"page":"208-213","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":58,"title":["Magnesium Status in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"31","author":[{"given":"Nicola","family":"Veronese","sequence":"first","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division, University of Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zurlo","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division, University of Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Solmi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Luchini","sequence":"additional","affiliation":[{"name":"Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Trevisan","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division, University of Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bano","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division, University of Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Manzato","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division, University of Padova, Italy"},{"name":"National Research Council, Neuroscience Institute, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Sergi","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division, University of Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnar","family":"Rylander","sequence":"additional","affiliation":[{"name":"BioFact Environmental Health Research Center, Lerum, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9,7]]},"reference":[{"key":"bibr1-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1038\/475S2a"},{"key":"bibr2-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040223"},{"key":"bibr3-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.582"},{"key":"bibr4-1533317515602674","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0272"},{"key":"bibr5-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12087"},{"key":"bibr6-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.05.1771"},{"issue":"3","key":"bibr7-1533317515602674","first-page":"189","volume":"13","author":"Andr\u00e1si E","year":"2000","journal-title":"Magnes Res"},{"key":"bibr8-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(90)90095-V"},{"key":"bibr9-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112002753"},{"key":"bibr10-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1038\/309261a0"},{"key":"bibr11-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.12.026"},{"issue":"5","key":"bibr12-1533317515602674","first-page":"257","volume":"18","author":"Ebel H","year":"1980","journal-title":"J Clin Chem Clin Biochem"},{"key":"bibr13-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.10.084"},{"key":"bibr14-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2005.01.005"},{"key":"bibr15-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"bibr16-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"bibr17-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"bibr18-1533317515602674","unstructured":"RevMan 5.3. Informatics & knowledge management department. http:\/\/tech.cochrane.org\/revman. Accessed May 4, 2015."},{"key":"bibr19-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"bibr20-1533317515602674","unstructured":"Comprehensive Meta-Analysis (CMA) 3.0. http:\/\/www.meta-analysis.com\/index.php. Accessed May 4, 2015."},{"key":"bibr21-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1684\/mrh.2011.0287"},{"key":"bibr22-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1159\/000110873"},{"key":"bibr23-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.01.003"},{"key":"bibr24-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00241-T"},{"issue":"4","key":"bibr25-1533317515602674","first-page":"231","volume":"3","author":"Basun H","year":"1991","journal-title":"J Neural Transm Park Dis Dement Sect"},{"issue":"4","key":"bibr26-1533317515602674","first-page":"283","volume":"3","author":"Borella P","year":"1990","journal-title":"Magnes Res"},{"key":"bibr27-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1159\/000249145"},{"key":"bibr28-1533317515602674","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1969.tb107155.x"},{"key":"bibr29-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2009.00571.x"},{"key":"bibr30-1533317515602674","first-page":"1095","volume":"317","author":"Kobayashi S","year":"1989","journal-title":"Prog Clin Biol Res"},{"key":"bibr31-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1984.tb00889.x"},{"key":"bibr32-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1177\/0891988714522698"},{"key":"bibr33-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2010.02.002"},{"key":"bibr34-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1002\/gps.934"},{"key":"bibr35-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1684\/mrh.2009.0187"},{"key":"bibr36-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1126\/science.7361117"},{"key":"bibr37-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00241-T"},{"key":"bibr38-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0347"},{"key":"bibr39-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.01.003"},{"issue":"2","key":"bibr40-1533317515602674","first-page":"249","volume":"206","author":"Hac E","year":"1997","journal-title":"Sci Total Environ"},{"key":"bibr41-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200109000-00008"},{"key":"bibr42-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.2.419"},{"key":"bibr43-1533317515602674","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.080168"},{"key":"bibr44-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-9961-3"},{"key":"bibr45-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.05.038"},{"key":"bibr46-1533317515602674","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00004"},{"key":"bibr47-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-014-0065-y"},{"key":"bibr48-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.12817"},{"key":"bibr49-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.9.2374"},{"key":"bibr50-1533317515602674","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91199-5"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317515602674","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533317515602674","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317515602674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:13Z","timestamp":1777368013000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317515602674"}},"subtitle":["A Systematic Review"],"short-title":[],"issued":{"date-parts":[[2015,9,7]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1177\/1533317515602674"],"URL":"https:\/\/doi.org\/10.1177\/1533317515602674","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,7]]}}}