{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:04Z","timestamp":1787019244781,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Severe Impairment Battery (SIB) data from the 24-week, randomized, double-blind ACTivities of daily living and cognitION (ACTION) study suggest that patients with severe Alzheimer\u2019s disease (AD) benefit from treatment with 13.3 versus 4.6 mg\/24 h rivastigmine patch. The objective of this retrospective analysis was to further examine the cognitive efficacy of 13.3 versus 4.6 mg\/24 h rivastigmine patch on individual SIB items, and SIB domains derived using factor analysis of these items. Change from baseline at Week 24 on 9 new factor-defined domains and individual items was calculated and compared using effect sizes (Cohen\u2019s d). Numerically less decline was observed with 13.3 versus 4.6 mg\/24 h patch on all domains and the majority of individual items. Largest least squares mean treatment differences were observed on \u201cvisuospatial reasoning,\u201d \u201cobject naming,\u201d \u201crecognition,\u201d \u201cdesign copying,\u201d \u201csocial agency,\u201d \u201cideational praxis,\u201d and \u201ccomprehension\u201d domains. These findings suggest 13.3 mg\/24 h rivastigmine patch demonstrates broad cognitive efficacy across a range of SIB items and domains in patients with severe AD.<\/jats:p>","DOI":"10.1177\/1533317515603687","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T21:29:23Z","timestamp":1442266163000},"page":"270-277","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Cognitive Efficacy (SIB) of 13.3 Versus 4.6 mg\/24 h Rivastigmine Patch in Severe Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"31","author":[{"given":"Richard S.","family":"Isaacson","sequence":"first","affiliation":[{"name":"Department of Neurology, Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Ferris","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neurology, Alzheimer\u2019s Disease Center, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew M.","family":"Velting","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Meng","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"key":"bibr1-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.2.3.298"},{"key":"bibr2-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540130067012"},{"key":"bibr3-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199700112-00008"},{"key":"bibr4-1533317515603687","unstructured":"Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA Exelon Patch\n                      \u00ae\n                      (rivastigmine tartrate) prescribing information. 2013. Web site: http:\/\/www.pharma.us.novartis.com\/product\/pi\/pdf\/exelonpatch.pdf. Accessed July 9, 2014."},{"key":"bibr5-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12158"},{"key":"bibr6-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.513849"},{"key":"bibr7-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199700112-00005"},{"key":"bibr8-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt229"},{"key":"bibr9-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"bibr10-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"bibr11-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4080"},{"key":"bibr12-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1177\/1533317511424892"},{"key":"bibr13-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-7421(08)60422-3"},{"key":"bibr14-1533317515603687","doi-asserted-by":"publisher","DOI":"10.1159\/000048640"},{"issue":"2","key":"bibr15-1533317515603687","first-page":"26","volume":"4","author":"Lopez-Pousa S","year":"2004","journal-title":"Brain Aging"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317515603687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533317515603687","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317515603687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:14Z","timestamp":1777368014000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533317515603687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,14]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1177\/1533317515603687"],"URL":"https:\/\/doi.org\/10.1177\/1533317515603687","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,14]]}}}