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Epigenetic changes can be acquired over the life span and mediate environmental effects on gene expression. DNA-methyltransferase 3A (DNMT3A) plays an important role in the development of embryogenesis and the generation of aberrant methylation late-onset AD (LOAD). In this study, the rs1550117 polymorphism of DNMT3A was determined by polymerase chain reaction\/restriction fragment length polymorphism and confirmed by sequencing. The results showed that AA genotype carriers had a 2.08-fold risk of developing LOAD in comparison with GG genotype carriers (odds ratio [OR] = 2.08, 95% confidence interval [CI]: 1.03-4.21, P = .038) and had a 2.05-fold risk for LOAD compared with GG+GA genotype carriers (OR = 2.05, 95% CI: 1.03-4.11, P = .038), indicating that the DNMT3A polymorphism supports a major role in the pathogenesis of LOAD and can be used as a stratification marker to predict an individual\u2019s susceptibility to LOAD.<\/jats:p>","DOI":"10.1177\/1533317515603688","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T21:29:23Z","timestamp":1442266163000},"page":"278-281","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["DNMT3A rs1550117 Polymorphism is Associated With Late-Onset Alzheimer\u2019s Disease in a Chinese Population"],"prefix":"10.1177","volume":"31","author":[{"given":"Chen","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Neurology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medicine University, Zhejiang, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Fangyu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhoushan Hospital, Zhejiang, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wanhua","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medicine University, Zhejiang, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Kelong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese 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