{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:42:51Z","timestamp":1779208971812,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>We investigated vascular functioning in patients with a clinical and radiological diagnosis of either Alzheimer\u2019s disease (AD) or vascular dementia (VaD) and examined a possible relationship between vascular function and cognitive status. Twenty-seven patients with AD, 23 patients with VaD, and 26 healthy control patients underwent measurements of flow-mediated dilation (FMD), ankle\u2013brachial index (ABI), cardioankle vascular index (CAVI), and intima\u2013media thickness (IMT). The FMD was significantly lower in patients with AD or VaD compared to controls. There were no significant differences in ABI, CAVI, or IMT among the 3 groups. A significant correlation was found between Mini-Mental State Examination (MMSE) scores and FMD. Furthermore, a multiple regression analysis revealed that FMD was significantly predicted by MMSE scores. These results suggest that endothelial involvement plays a role in AD pathogenesis, and FMD may be more sensitive than other surrogate methods (ABI, CAVI, and IMT) for detecting early-stage atherosclerosis and\/or cognitive decline.<\/jats:p>","DOI":"10.1177\/1533317516653820","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T21:10:44Z","timestamp":1465506644000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Vascular Function in Alzheimer\u2019s Disease and Vascular Dementia"],"prefix":"10.1177","volume":"31","author":[{"given":"Hisatsugu","family":"Tachibana","sequence":"first","affiliation":[{"name":"Division of Neurology, Graduate School of Medicine, Kobe University, Chuo-ku, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Washida","sequence":"additional","affiliation":[{"name":"Division of Neurology, 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