{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:22:42Z","timestamp":1793035362929,"version":"4.5.0"},"reference-count":77,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The association of variants in CLU, CR1, PICALM, BIN1, ABCA7, and CD33 genes with late-onset Alzheimer\u2019s disease (LOAD) was evaluated and confirmed through genome-wide association study. However, it is unknown whether these associations can be replicated in admixed populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The association of 14 single-nucleotide polymorphisms in those genes was evaluated in 280 LOAD cases and 357 controls from the Colombian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In a multivariate analysis using age, gender, APOE\u220a4 status, and admixture covariates, significant associations were obtained ( P &lt; .05) for variants in BIN1 (rs744373, odds ratio [OR]: 1.42), CLU (rs11136000, OR: 0.66), PICALM (rs541458, OR: 0.69), ABCA7 (rs3764650, OR: 1.7), and CD33 (rs3865444, OR: 1.12). Likewise, a significant interaction effect was observed between CLU and CR1 variants with APOE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study replicated the associations previously reported in populations of European ancestry and shows that APOE variants have a regulatory role on the effect that variants in other loci have on LOAD, reflecting the importance of gene\u2013gene interactions in the etiology of neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533317516679303","type":"journal-article","created":{"date-parts":[[2017,1,14]],"date-time":"2017-01-14T01:16:50Z","timestamp":1484356610000},"page":"27-35","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Association of\n                    <i>GWAS<\/i>\n                    Top Genes With Late-Onset Alzheimer\u2019s Disease in Colombian Population"],"prefix":"10.1177","volume":"32","author":[{"given":"Diana Jennifer","family":"Moreno","sequence":"first","affiliation":[{"name":"Grupo de Gen\u00e9tica Molecular, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Grupo de Gen\u00e9tica Molecular, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Grupo de Neuropsicolog\u00eda, Universidad Surcolombiana, Neiva, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Lopera","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Ostos","sequence":"additional","affiliation":[{"name":"Grupo de Medicina Gen\u00f3mica, Universidad Surcolombiana, Neiva, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Via","sequence":"additional","affiliation":[{"name":"Psicologia Cl\u00ednica i Psicobiologia and Institut de Neuroci\u00e8ncies, Universitat de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Bedoya","sequence":"additional","affiliation":[{"name":"Grupo de Gen\u00e9tica Molecular, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"bibr1-1533317516679303","volume-title":"Dementia: A Public Health Priority","author":"International WHO and Alzheimer\u2019s Disease 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