{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:01:47Z","timestamp":1777381307363,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Rationale:<\/jats:title>\n                    <jats:p>Accumulating evidence suggests that the use of angiotensin-converting enzyme inhibitor (ACE-I) medication protects against cognitive decline in the elderly patients. We investigated whether ACE-I use was associated with higher plasma levels of amyloid-\u03b2 (A\u03b2), possibly indicating improved A\u03b2 clearance from brain to blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We measured and compared plasma concentrations of A\u03b242, A\u03b240, and creatinine in cognitively impaired individuals with amnestic mild cognitive impairment, probable Alzheimer\u2019s disease (AD) dementia, and mixed probable AD\/vascular dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Plasma A\u03b242 levels and A\u03b242\/A\u03b240 ratios of participants taking ACE-Is (n = 11) significantly exceeded ( t = 3.1, df = 19, P = .006; U = 24, P = .029, respectively) those not taking ACE-Is (n = 10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study is the first to show an association between ACE-I use and increased plasma A\u03b242 level and A\u03b242\/A\u03b240 ratio in cognitively impaired individuals. Future investigations should assess whether a possible ACE-I-induced increase in plasma A\u03b242 indicates improved A\u03b242 clearance from brain that contributes to protection from cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533317517707288","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T01:27:08Z","timestamp":1493342828000},"page":"347-352","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Elevated Plasma A\u03b242 in Cognitively Impaired Individuals Taking ACE Inhibitor Antihypertensives"],"prefix":"10.1177","volume":"32","author":[{"given":"William T.","family":"Regenold","sequence":"first","affiliation":[{"name":"Department of Psychiatry (Geriatric), University of Maryland School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-1536","authenticated-orcid":false,"given":"Jacob B.","family":"Blumenthal","sequence":"additional","affiliation":[{"name":"GRECC, Baltimore VA Medical Center, Baltimore, MD, USA"},{"name":"Division of Gerontology and Geriatric Medicine\/Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Loreck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Geriatric), University of Maryland School of Medicine, Baltimore, MD, USA"},{"name":"VA Maryland Health Care System, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen L.","family":"Mordecai","sequence":"additional","affiliation":[{"name":"VA Maryland Health Care System, Baltimore, MD, 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