{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:42:32Z","timestamp":1788579752416,"version":"build-2803163510"},"reference-count":60,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Yousef Abdullatif Jameel (YAJ) Scientific Chair of Prophetic Medical Applications, King Abdulaziz University, Jeddah, Saudi Arabia"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effect induced by musk on Alzheimer\u2019s disease\u2014such as neurodegenerative changes in mice exposed to chronic unpredictable mild stress (CUMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Forty male Swiss albino mice were divided into 4 groups (n = 10); control, CUMS, CUMS + fluoxetine, CUMS + musk. At the end of the experiment, behavior of the mice was assessed. Serum corticosterone level, hippocampal protein level of the glucocorticoid receptors, and brain-derived neurotropic factor were also assessed. Hippocampus was histopathologically examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Musk improved depressive status induced after exposure to CUMS as evidenced by the forced swimming and open field tests and improved the short-term memory as evidenced by the elevated plus maze test. Musk reduced both corticosterone levels and the hippocampal neurodegenerative changes observed after exposure to CUMS. These improvements were comparable to those induced by fluoxetine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Musk alleviated the memory impairment and neurodegenerative changes induced after exposure to the chronic stress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533317518755993","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:30:18Z","timestamp":1517445018000},"page":"221-231","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["The Role of Musk in Relieving the Neurodegenerative Changes Induced After Exposure to Chronic Stress"],"prefix":"10.1177","volume":"33","author":[{"given":"Manal Galal","family":"Abd El Wahab","sequence":"first","affiliation":[{"name":"Anatomy department, Faculty of Medicine for Girls Al Azhar University, Cairo, Egypt"},{"name":"Basic Sciences department, Nursing College, King Saud Bin Abd El Aziz University, National guard, Jeddah, Saudi Arabia"},{"name":"Yousef Abdullatif Jameel, Chair of Prophetic Medical Applications (YAJCPMA), Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad Shaker","family":"Ali","sequence":"additional","affiliation":[{"name":"Yousef Abdullatif Jameel, Chair of Prophetic Medical Applications (YAJCPMA), Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"},{"name":"Anatomy department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasra Naeim","family":"Ayuob","sequence":"additional","affiliation":[{"name":"Anatomy department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"},{"name":"Histology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"bibr1-1533317518755993","unstructured":"World Alzheimer Report 2016. 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