{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:57:03Z","timestamp":1793728623516,"version":"4.6.1"},"reference-count":82,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005370","name":"Gates Cambridge Trust","doi-asserted-by":"crossref","award":["K01 DK105110-01"],"award-info":[{"award-number":["K01 DK105110-01"]}],"id":[{"id":"10.13039\/501100005370","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pregnancy is associated with improvement in immunoregulation that persists into the geriatric phase. Impaired immunoregulation is implicated in Alzheimer\u2019s disease (AD) pathogenesis. Hence, we investigate the relationship between pregnancy and AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Cross-sectional cohort of British women (N = 95). Cox proportional hazards modeling assessed the putative effects of cumulative months pregnant on AD risk and the mutually adjusted effects of counts of first and third trimesters on AD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Cumulative number of months pregnant, was associated with lower AD risk (\u03b2 = \u22121.90, exp(\u03b2) = 0.15, P = .02). Cumulative number of first trimesters was associated with lower AD risk after adjusting for third trimesters (\u03b2 = \u22123.83, exp(\u03b2) = 0.02, P &lt; .01), while the latter predictor had no significant effect after adjusting for the former.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our observation that first trimesters (but not third trimesters) conferred protection against AD is more consistent with immunologic effects, which are driven by early gestation, than estrogenic exposures, which are greatest in late gestation. Results may justify future studies with immune biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533317518786447","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T01:36:45Z","timestamp":1533001005000},"page":"516-526","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":62,"title":["Women\u2019s Pregnancy Life History and Alzheimer\u2019s Risk: Can Immunoregulation Explain the Link?"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-8971","authenticated-orcid":false,"given":"Molly","family":"Fox","sequence":"first","affiliation":[{"name":"Department of Anthropology, University of California, Los Angeles, Los Angeles, CA, USA"},{"name":"Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, 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