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A large body of research has demonstrated that slow motor performance is associated with cognitive impairment in elderly people. The interdependence between motor dysfunction and cognition decline is still not fully understood. Although several factors have been suggested to give a plausible explanation, \u03b2-amyloid (A\u03b2) and \u03c4-protein aggregation is a common feature of a number of neurodegenerative disorders which are characterized by both motor and cognitive impairment, and it is assumed that the aggregation process plays a central role in the pathogenesis of cognitive impairment and motor dysfunction in Alzheimer\u2019s disease. The purpose of the present review is to provide an overview of the available evidence that can help to better elucidate the pathophysiological mechanisms underlying the relationship between cognitive and movement disturbances by focusing on A\u03b2 and \u03c4-protein.<\/jats:p>","DOI":"10.1177\/1533317518790631","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T01:32:08Z","timestamp":1532568728000},"page":"535-540","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Neurochemical Aspects of Alzheimer\u2019s Disease and Movement Disturbances: A Theory of \u03b2-Amyloid and \u03c4-Protein"],"prefix":"10.1177","volume":"33","author":[{"given":"Auda","family":"Fares","sequence":"first","affiliation":[{"name":"Department of Acute Geriatric Medicine & Rehabilitation, St Willibrord-Spital Emmerich-Rees, Emmerich, 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