{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:55:46Z","timestamp":1784634946232,"version":"3.55.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Eli Lilly Japan K.K."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>This study aimed to assess efficacy and limitations of regional cerebral blood flow imaging using single-photon emission computed tomography (rCBF-SPECT) in the diagnosis of Alzheimer\u2019s disease (AD) with amyloid-positron emission tomography (amyloid-PET). Thirteen patients, who underwent both rCBF-SPECT and amyloid-PET after clinical diagnosis of AD or mild cognitive impairment, were retrospectively identified. The rCBF-SPECTs were classified into 4 grades, from typical AD pattern to no AD pattern of hypoperfusion; amyloid-beta (A\u03b2) positivity was assessed by amyloid-PET. Four patients were categorized into a typical AD pattern on rCBF-SPECT, and all were A\u03b2+. The other 9 patients did not exhibit a typical AD pattern; however, 4 were A\u03b2+. The Mini-Mental State Examination score and Clinical Dementia Rating scale were not significantly different between A\u03b2+ and A\u03b2\u2013 patients. A typical AD pattern on rCBF-SPECT can reflect A\u03b2+; however, if not, rCBF-SPECT has a limitation to predict amyloid pathology.<\/jats:p>","DOI":"10.1177\/1533317519841192","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T01:04:03Z","timestamp":1554858243000},"page":"314-321","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Limitations of rCBF-SPECT in the Diagnosis of Alzheimer\u2019s Disease With Amyloid-PET"],"prefix":"10.1177","volume":"34","author":[{"given":"Miwako","family":"Takahashi","sequence":"first","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Tada","sequence":"additional","affiliation":[{"name":"Eli Lilly Japan K.K., Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Eli Lilly Japan K.K., Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Koyama","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-400X","authenticated-orcid":false,"given":"Toshimitsu","family":"Momose","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"key":"bibr1-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67889-0"},{"key":"bibr2-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"bibr3-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2012.00415.x"},{"key":"bibr5-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70142-4"},{"key":"bibr6-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.186.2.8421735"},{"key":"bibr7-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.202.3.9051035"},{"issue":"1","key":"bibr8-1533317519841192","first-page":"29","volume":"35","author":"Kumakura Y","year":"1998","journal-title":"Kaku Igaku"},{"key":"bibr9-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.3.474"},{"key":"bibr10-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1159\/000320265"},{"issue":"7","key":"bibr11-1533317519841192","first-page":"1155","volume":"41","author":"Kogure D","year":"2000","journal-title":"J Nucl Med"},{"key":"bibr12-1533317519841192","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111850"},{"key":"bibr13-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.066"},{"key":"bibr14-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.096800"},{"key":"bibr15-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3477-0"},{"key":"bibr16-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1111\/ncn3.12107"},{"key":"bibr17-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.2008"},{"key":"bibr18-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31821300bc"},{"key":"bibr19-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-015-0978-2"},{"key":"bibr20-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"bibr21-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"bibr22-1533317519841192","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.069088"},{"key":"bibr23-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.7.950"},{"key":"bibr24-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"bibr25-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30077-7"},{"key":"bibr26-1533317519841192","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530340029014"},{"issue":"11","key":"bibr27-1533317519841192","first-page":"1842","volume":"41","author":"Meltzer CC","year":"2000","journal-title":"J Nucl Med"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317519841192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533317519841192","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533317519841192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:49Z","timestamp":1777368049000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/1533317519841192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,9]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,9]]},"published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1177\/1533317519841192"],"URL":"https:\/\/doi.org\/10.1177\/1533317519841192","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,9]]}}}