{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:04:54Z","timestamp":1777381494593,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>The aim of this study is to investigate the impact of optimal antihypertensive medication on cognitive function. In this 6-month clinical trial, 248 adults were randomly selected by a registry of hypertensive-treated patients (based on a National Hypertension Treatment Program), followed health centers located in Rafsanjan County, Southeast, Iran. Blood pressure was measured 3 times in each appointment pre- and posttreatment. Mini-Mental State Examination was used for cognitive performance evaluation. Paired t test and multiple regression model showed significant correlation between \u201cthe differences of systolic and diastolic blood pressure levels\u201d and \u201ccognitive performance in treated patients more than 40 years old.\u201d Cognitive performance was not significantly different in patients less than 40 years old post antihypertensive treatment. Cognitive performance scores demonstrated significant increase in responders more than 40 years old post antihypertensive treatment. Antihypertensive treatment in responders with age equal or more than 40 years improves the level of cognitive performance significantly.<\/jats:p>","DOI":"10.1177\/1533317519859197","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T23:54:44Z","timestamp":1563407684000},"page":"486-491","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Age-Related Effect of Antihypertensive Treatment on Cognitive Performance: Is it Better Preventing Dementia in Older Age?"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-7631","authenticated-orcid":false,"given":"Reza","family":"Vazirinejad","sequence":"first","affiliation":[{"name":"Social Determinants of Health Research Centre, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Mirmotalebi","sequence":"additional","affiliation":[{"name":"Social Medicine Department, Medical School, Rafsanjan University, Rafsanjan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monireh","family":"Bageri","sequence":"additional","affiliation":[{"name":"Social Medicine Department, Medical School, Rafsanjan University, Rafsanjan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas G.","family":"Kounis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Patras School of Medicine, Patras, Achaia, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Koniari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Queen Elizabeth University Hospital, Birmingham, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette M.","family":"Lilley","sequence":"additional","affiliation":[{"name":"Applied Gerontology, Division of Rehabilitation and Ageing, The Medical School, Queens Medical Centre, Nottingham University, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Gommnami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Islamic Azad University Mashhad Branch, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"bibr1-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.105577"},{"key":"bibr2-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000145858.07252.99"},{"key":"bibr3-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.08.057"},{"key":"bibr4-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.18.2046"},{"key":"bibr5-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.8.991"},{"key":"bibr6-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000098934.18300.BE"},{"key":"bibr7-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.1.66"},{"key":"bibr8-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199002000-00008"},{"key":"bibr9-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200305000-00011"},{"key":"bibr10-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1590\/S0101-60832010000200004"},{"key":"bibr11-1533317519859197","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-12-201106210-00005"},{"key":"bibr12-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380050029006"},{"issue":"1","key":"bibr13-1533317519859197","first-page":"19","volume":"143","author":"Campbell NRC","year":"1990","journal-title":"CMAJ"},{"key":"bibr14-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000249685.58370.28"},{"issue":"1","key":"bibr15-1533317519859197","first-page":"CD002003","author":"Wiysonge CS","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr16-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehb.2007.03.002"},{"key":"bibr17-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022925"},{"key":"bibr18-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.4.2.226"},{"key":"bibr19-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.6.1079"},{"key":"bibr20-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03086-4"},{"key":"bibr21-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.1948"},{"key":"bibr22-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.1.42"},{"key":"bibr23-1533317519859197","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70141-1"}],"container-title":["American Journal of Alzheimer's Disease &amp; 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