{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:24:46Z","timestamp":1793741086273,"version":"4.6.1"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Liaoning Provincial Natural Science Foundation of China","award":["Grant No. L20170541014"],"award-info":[{"award-number":["Grant No. L20170541014"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>Tyrosine kinase receptor A (TrkA) plays an important role in the protection of cholinergic neurons in Alzheimer\u2019s disease (AD). This study was designed to investigate whether \u03b2-hydroxybutyrate (BHB), an endogenous histone deacetylase (HDAC) inhibitor, upregulates the expression of TrkA by affecting histone acetylation in SH-SY5Y cells treated with amyloid \u03b2-protein (A\u03b2). The results showed that BHB ameliorated the reduction of cell vitality and downregulation of TrkA expression induced by A\u03b2. Furthermore, BHB inhibited the upregulation of HDAC1\/2\/3 expression and downregulation of histone acetylation (Ace-H3K9 and Ace-H4K12) levels in A\u03b2-treated cells. The expression of TrkA was upregulated in HDAC1- or 3-silenced SH-SY5Y cells. However, there was no significant difference in TrkA expression between the HDAC2 knockdown and control cells. In conclusion, this study demonstrates that BHB protects against A\u03b2-induced neurotoxicity in SH-SY5Y cells. The underlying mechanism of the effect may be associated with the upregulation of TrkA expression by inhibiting HDAC1\/3.<\/jats:p>","DOI":"10.1177\/1533317519883496","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:34:16Z","timestamp":1571963656000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["\u03b2-Hydroxybutyrate Ameliorates A\u03b2-Induced Downregulation of TrkA Expression by Inhibiting HDAC1\/3 in SH-SY5Y Cells"],"prefix":"10.1177","volume":"35","author":[{"given":"Xinhui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical 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