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After 1 year of observation, cognitive and functional scores worsened while behavioral problems remained unchanged and relatively mild in patients. After 1 year, caregivers\u2019 scores of scales of anxiety and depression decreased significantly, while stress scores remained unchanged and burden slightly increased. In our opinion, the unexpected improvement in psychological situation of caregivers may be mainly due to educational interventions focused on knowledge of the disease with a particular attention directed toward emotional support and individual needs.<\/jats:p>","DOI":"10.1177\/1533317519899544","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T06:26:10Z","timestamp":1581575170000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Anxiety and Depression Are Not Related to Increasing Levels of Burden and Stress in Caregivers of Patients With Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"35","author":[{"given":"Tiziana","family":"Tentorio","sequence":"first","affiliation":[{"name":"Neurology Department, Multimedica Hospital, Castellanza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Dentali","sequence":"additional","affiliation":[{"name":"Neurology Department, Multimedica Hospital, Castellanza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Moioli","sequence":"additional","affiliation":[{"name":"Neurology Department, Multimedica Hospital, Castellanza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Zuffi","sequence":"additional","affiliation":[{"name":"Neurology Department, Multimedica Hospital, Castellanza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosy","family":"Marzullo","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Riposo e Cura per Anziani (INRCA), Fermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Neurology Department, Multimedica Hospital, Castellanza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-8392","authenticated-orcid":false,"given":"Massimo","family":"Franceschi","sequence":"additional","affiliation":[{"name":"Neurology Department, Multimedica Hospital, Castellanza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"bibr1-1533317519899544","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.63"},{"key":"bibr2-1533317519899544","unstructured":"World Alzheimer Report 2015. 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