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To examine the effect of multiple medicines on the initiation of anti-dementia therapy in patients diagnosed with cognitive impairment (CI), a retrospective study with 2742 CI patients was conducted based on the outpatients\u2019 medical records. The dementias receiving 1\u20132 drugs were more likely to be prescribed with anti-dementia (one drug: OR = 1.877; two drugs: OR = 1.770) and psychotropic (one drug: OR = 1.980) treatment, whereas had lower chances of receiving psychotropic medication with the combinations of more than three drugs (Alzheimer\u2019s disease: OR = .365; vascular dementia: OR = .940; frontotemporal lobe degeneration: OR = .957; and dementia with Lewy bodies\/Parkinson\u2019s disease dementia: OR = .952). Multiple medicines can affect anti-dementia therapy initiation in dementia patients and should be paid extreme caution.<\/jats:p>","DOI":"10.1177\/15333175211053134","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T08:11:41Z","timestamp":1638173501000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Multiple Medicines on Dementia Initial Treatment: Experience and Thinking"],"prefix":"10.1177","volume":"36","author":[{"given":"Jinghuan","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin, University Traditional Chinese Medicine, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-6996","authenticated-orcid":false,"given":"Yong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, China"},{"name":"Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"bibr1-15333175211053134","first-page":"61","volume":"51","author":"Arbanas G","year":"2015","journal-title":"Alcohol Psychiatry Res"},{"key":"bibr2-15333175211053134","unstructured":"Prince M, Guerchet M, Prina M. 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