{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:26:56Z","timestamp":1780082816031,"version":"3.54.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RF1AG050967, KL2 TR000450"],"award-info":[{"award-number":["1RF1AG050967, KL2 TR000450"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Investigators report greater parietal tau deposition and alternate frontoparietal network involvement in early onset Alzheimer\u2019s Disease (EOAD) with onset &lt;65\u00a0years as compared with typical late onset AD (LOAD). To determine whether clinical brain MRI volumes reflect these differences in EOAD compared with LOAD. This study investigated the clinical MRI scans of 45 persons with Clinically Probable AD with onset &lt;65\u00a0years, and compared them to 32 with Clinically Probable AD with onset \u226565\u00a0years. Brain volumes on their T1 MRI scans were quantified with a volumetric program. Receiver operating curve analyses were performed. Persons with EOAD had significantly smaller parietal lobes (volumetric percentiles) than LOAD. Late onset Alzheimer\u2019s Disease had a smaller left putamen and hippocampus. Area Under the Curve was 96 .5% with brain region delineation of EOAD compared to LOAD. This study indicates parietal atrophy less than 30% of normal on clinical MRI scans is suggestive of EOAD compared to LOAD.<\/jats:p>","DOI":"10.1177\/15333175211055325","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T01:50:57Z","timestamp":1637718657000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Quantitative MRI Differences Between Early versus Late Onset Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"36","author":[{"given":"Somayeh","family":"Meysami","sequence":"first","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-0105","authenticated-orcid":false,"given":"Cyrus A.","family":"Raji","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology, Division of Neuroradiology, Washington University in St Louis, St Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-3839","authenticated-orcid":false,"given":"David A.","family":"Merrill","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"},{"name":"Providence and St Johns Health Center, Pacific Neuroscience Institute, Santa Monica, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verna R.","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"},{"name":"Providence and St Johns Health Center, Pacific Neuroscience Institute, Santa Monica, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario F.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"},{"name":"Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"},{"name":"V.A. 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