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Methods: A retrospective cohort study of 33,456 participants from the National Alzheimer\u2019s Coordinating Center database. Results: Participants with one or two APOE \u03b54 alleles had 2.71 (CI:2.55\u20132.88) and 9.37 (CI:8.14\u201310.78) times higher odds of AD diagnosis, respectively, relative to those with zero \u03b54 alleles. In contrast, diabetic participants showed 1.07 (CI:0.96\u20131.18) times higher odds of AD relative to nondiabetics. Diabetes did not exacerbate the odds of AD in APOE \u03b54 carriers. APOE \u03b54 carriage was correlated with declines in long-term memory and verbal fluency, which were strongly correlated with conversion to AD. However, diabetes was correlated with working memory decline, which had a relatively weak correlation with AD. Conclusions: Unlike APOE \u03b54, there was little evidence that diabetes was a risk factor for AD.<\/jats:p>","DOI":"10.1177\/15333175211070912","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T14:35:29Z","timestamp":1642516529000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9433-2433","authenticated-orcid":false,"given":"Kaushik","family":"Ravipati","sequence":"first","affiliation":[{"name":"Neuroscience and Behavioral Biology, Emory University, Atlanta, GA USA"},{"name":"Florida International University Herbert Wertheim College of Medicine, Miami, FL 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