{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:16:37Z","timestamp":1789517797904,"version":"build-2803163510"},"reference-count":51,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG056279"],"award-info":[{"award-number":["R01AG056279"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>(Genome-wide Association Studies) GWAS have identified \u223c42 late-onset Alzheimer\u2019s disease (LOAD)-associated loci, each of which contains multiple single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) and most of these SNPs are in the non-coding region of human genome. However, how these SNPs regulate risk gene expression remains unknown. In this work, by using a set of novel techniques, we identified 6 functional SNPs (fSNPs) rs9271198, rs9271200, rs9281945, rs9271243, and rs9271247 on the LOAD-associated HLA-DRB1\/DQA1 locus and 42 proteins specifically binding to five of these 6 fSNPs. As a proof of evidence, we verified the allele-specific binding of GATA2 and GATA3, ELAVL1 and HNRNPA0, ILF2 and ILF3, NFIB and NFIC, as well as CUX1 to these five fSNPs, respectively. Moreover, we demonstrate that all these nine proteins regulate the expression of both HLA-DQA1 and HLA-DRB1 in human microglial cells. The contribution of HLA class II to the susceptibility of LOAD is discussed.<\/jats:p>","DOI":"10.1177\/15333175221085066","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T23:11:20Z","timestamp":1648336280000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Regulation of the Late Onset alzheimer\u2019s Disease Associated\n                    <i>HLA-DQA1\/DRB1<\/i>\n                    Expression"],"prefix":"10.1177","volume":"37","author":[{"given":"Xiaoyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Aging Institute, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijaun","family":"Zou","sequence":"additional","affiliation":[{"name":"Aging Institute, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Pharmacology, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Aging Institute, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Medicine, Xiangya School of Medicine, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danli","family":"Jiang","sequence":"additional","affiliation":[{"name":"Aging Institute, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wu","sequence":"additional","affiliation":[{"name":"Aging Institute, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Medicine, Xiangya School of Medicine, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Aging Institute, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC, USA"},{"name":"Department of Periodontology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-6611","authenticated-orcid":false,"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Aging Institute, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"bibr1-15333175221085066","unstructured":"Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. 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