{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:27:15Z","timestamp":1789432035208,"version":"build-2803163510"},"reference-count":113,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Fund of Talent Launch Project of Oujiang Laboratory","award":["OJQDSP2022011"],"award-info":[{"award-number":["OJQDSP2022011"]}]},{"name":"Beijing Natural Science Foundation","award":["M21004"],"award-info":[{"award-number":["M21004"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071214"],"award-info":[{"award-number":["82071214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>\n                    Most of neurodegenerative diseases (NDD) have no cure. The common etiology of neurodegenerations is unclear. Air pollutant-gaseous formaldehyde is notoriously known to induce demyelination and cognitive impairments. Unexpectedly, an amount of formaldehyde has been detected in the brains. Multiple factors can induce the generation and accumulation of endogenous formaldehyde. Excessive formaldehyde can induce oxidative stress to generate H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ; in turn, H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    promote formaldehyde production. Clinical investigations have shown that an abnormal high level of formaldehyde but low level of coenzyme Q10 (coQ10) was observed in patients with NDD. Further studies have proven that excessive formaldehyde directly inactivates coQ10, reduces the ATP generation, enhances oxidative stress, initiates inflammation storm, induces demyelination; subsequently, it results in neurodegeneration. Although the low water solubility of coQ10 limits its clinical application, nanomicellar water-soluble coQ10 exhibits positive therapeutical effects. Hence, nanopackage of coQ10 may be a promising strategy for treating NDD.\n                  <\/jats:p>","DOI":"10.1177\/15333175221143274","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T15:19:05Z","timestamp":1669907945000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-3028","authenticated-orcid":false,"given":"Jinan","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Ningbo, Wenzhou Medical University, Wenzhou, China"},{"name":"Key Laboratory of Alzheimer\u2019s Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjiang","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Alzheimer\u2019s Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuting","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory of Alzheimer\u2019s Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Alzheimer\u2019s Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Alzheimer\u2019s Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-0386","authenticated-orcid":false,"given":"Zhiqian","family":"Tong","sequence":"additional","affiliation":[{"name":"Institute of Ningbo, Wenzhou Medical University, Wenzhou, China"},{"name":"Key Laboratory of Alzheimer\u2019s Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"bibr1-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.11.019"},{"key":"bibr2-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11070940"},{"key":"bibr3-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020215"},{"key":"bibr4-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0668.2008.00524.x"},{"key":"bibr5-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/16.1.33"},{"key":"bibr6-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200090808"},{"key":"bibr7-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.07.013"},{"key":"bibr8-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101512"},{"key":"bibr9-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.09.007"},{"key":"bibr10-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.09.026"},{"key":"bibr11-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c04520"},{"key":"bibr12-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00929-7"},{"key":"bibr13-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-310750"},{"issue":"2","key":"bibr14-15333175221143274","first-page":"45","volume":"89","author":"Khokhlov A","year":"1989","journal-title":"Zhurnal nevropatologii i psikhiatrii imeni SS Korsakova"},{"key":"bibr15-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0369-4"},{"key":"bibr16-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4666(05)80008-0"},{"key":"bibr17-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/704678"},{"key":"bibr18-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2014.994036"},{"key":"bibr19-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.184"},{"key":"bibr20-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180467"},{"key":"bibr21-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0492-y"},{"key":"bibr22-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-201983"},{"key":"bibr23-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-013-1416-x"},{"key":"bibr24-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23130"},{"key":"bibr25-15333175221143274","first-page":"159","author":"Matsubara T","year":"1991","journal-title":"Biomed Clin Aspec of Coenzy Q"},{"key":"bibr26-15333175221143274","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ana.410420221","volume":"42","author":"Shults C","year":"1997","journal-title":"Ann Neurol"},{"key":"bibr27-15333175221143274","doi-asserted-by":"publisher","DOI":"10.5607\/en20042"},{"key":"bibr28-15333175221143274","first-page":"597","volume":"5","author":"Spindler M","year":"2009","journal-title":"Neuropsychiatric Dis Treat"},{"key":"bibr29-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081325"},{"key":"bibr30-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1038\/nature23481"},{"issue":"1","key":"bibr31-15333175221143274","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-018-0242-0","volume":"2","author":"Ai L","year":"2019","journal-title":"Commun Biol"},{"key":"bibr32-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131595"},{"key":"bibr33-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1038\/srep01807"},{"key":"bibr34-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9388-8"},{"key":"bibr35-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022478221421"},{"key":"bibr36-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160357"},{"key":"bibr37-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701239R"},{"key":"bibr38-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau3333"},{"key":"bibr39-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200393"},{"key":"bibr40-15333175221143274","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.9.6160"},{"key":"bibr41-15333175221143274","first-page":"157","volume":"52","author":"Rozylo TK","year":"1997","journal-title":"Ann Univ Mariae Curie Sklodowska Med"},{"key":"bibr42-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0801(200005)14:3<173::AID-BMC957>3.0.CO;2-O"},{"key":"bibr43-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0834-x"},{"key":"bibr44-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1007\/BF03543014"},{"key":"bibr45-15333175221143274","doi-asserted-by":"publisher","DOI":"10.2131\/jts.41.479"},{"key":"bibr46-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.12"},{"key":"bibr47-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000629"},{"key":"bibr48-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.04.028"},{"key":"bibr49-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100428"},{"key":"bibr50-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-00520-2"},{"key":"bibr51-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.12.006"},{"key":"bibr52-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101512"},{"key":"bibr53-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0244-7"},{"key":"bibr54-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.04.004"},{"key":"bibr55-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02516-5"},{"key":"bibr56-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly024"},{"key":"bibr57-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00735"},{"key":"bibr58-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8100421"},{"key":"bibr59-15333175221143274","author":"Tao R","year":"2021","journal-title":"Anal Chem"},{"key":"bibr60-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216764"},{"key":"bibr61-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.09.020"},{"key":"bibr62-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55427-w"},{"issue":"1","key":"bibr63-15333175221143274","first-page":"140","volume":"87","author":"Chan T","year":"2003","journal-title":"J Neurochem"},{"key":"bibr64-15333175221143274","doi-asserted-by":"publisher","DOI":"10.2174\/156720512799015064"},{"key":"bibr65-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701239R"},{"key":"bibr66-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1007\/s007020070047"},{"key":"bibr67-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12356"},{"key":"bibr68-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.156976"},{"key":"bibr69-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13849"},{"key":"bibr70-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn105"},{"key":"bibr71-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-015-9309-6"},{"key":"bibr72-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1159\/000046889"},{"key":"bibr73-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.07.017"},{"key":"bibr74-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.6529"},{"key":"bibr75-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.01.025"},{"key":"bibr76-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.11.010"},{"key":"bibr77-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.3.599-a"},{"key":"bibr78-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2014.07.004"},{"key":"bibr79-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.07.013"},{"key":"bibr80-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.08.056"},{"issue":"1","key":"bibr81-15333175221143274","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-01566-0","volume":"4","author":"Yao D","year":"2021","journal-title":"Commun Bio"},{"key":"bibr82-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520090223"},{"key":"bibr83-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1177\/0884533610373932"},{"key":"bibr84-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-201981"},{"key":"bibr85-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1177\/1756286418819074"},{"issue":"12","key":"bibr86-15333175221143274","first-page":"68","volume":"12","author":"Zavalishin I","year":"1987","journal-title":"Vrach Delo"},{"issue":"1","key":"bibr87-15333175221143274","first-page":"125","volume":"52","author":"Khalilian B","year":"2021","journal-title":"Mol Neurobiol"},{"issue":"4","key":"bibr88-15333175221143274","first-page":"203","volume":"18","author":"Soleimani M","year":"2014","journal-title":"Iran Biomed J"},{"key":"bibr89-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1179\/1476830513Y.0000000106"},{"key":"bibr90-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2013.801844"},{"key":"bibr91-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010002"},{"key":"bibr92-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110209"},{"key":"bibr93-15333175221143274","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170275"},{"key":"bibr94-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109223"},{"key":"bibr95-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.02.002"},{"key":"bibr96-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(95)90033-0"},{"key":"bibr97-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.09.069"},{"key":"bibr98-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1076\/noph.19.3.113.7896"},{"key":"bibr99-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00185-X"},{"key":"bibr100-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.131"},{"key":"bibr101-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1038\/nature05292"},{"key":"bibr102-15333175221143274","doi-asserted-by":"publisher","DOI":"10.2174\/138945010790031018"},{"key":"bibr103-15333175221143274","doi-asserted-by":"publisher","DOI":"10.2174\/18715273113129990071"},{"key":"bibr104-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(84)90131-2"},{"key":"bibr105-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1179\/1476830515Y.0000000002"},{"key":"bibr106-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.09.004"},{"key":"bibr107-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e3180415e42"},{"key":"bibr108-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:17:2:101"},{"key":"bibr109-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.08.010"},{"key":"bibr110-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.02.016"},{"key":"bibr111-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/175062"},{"key":"bibr112-15333175221143274","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2018.10.010"},{"key":"bibr113-15333175221143274","volume":"242","author":"Zhang Y","year":"2019","journal-title":"IOP Conf Ser Earth Environ Sci"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15333175221143274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15333175221143274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15333175221143274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:19Z","timestamp":1777368019000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15333175221143274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":113,"alternative-id":["10.1177\/15333175221143274"],"URL":"https:\/\/doi.org\/10.1177\/15333175221143274","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"article-number":"15333175221143274"}}