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Gut microbial dysbiosis is associated with AD. This study involves the comparative assessment of spatial learning, \u03b2-amyloid peptide accumulation, and fecal microbiota alterations in 3\u00d7Tg-AD mice from 3 age groups: AD asymptomatic stage (3\u00a0m), presymptomatic stage (6\u00a0m), and the symptomatic stage of AD (9\u00a0m). We demonstrate that spatial memory deficits, brain A\u03b2 accumulation, and weight gain in 3\u00d7Tg-AD mice gradually appear after 6 months of age. However, the total gut bacterial counts underwent changes from 3 to 6\u00a0months of age and were further altered at 9\u00a0months of age. Importantly, changes in gut bacteria abundance of Desulfobacterota and Actinobacteriota phyla in 6-month-old mice preceded apparent spatial memory deficits. 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