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Pathological aging of the nervous system results in a series of neurodegenerative diseases and can cause disability and death in the elderly. Therefore, there is an urgent need for the prevention and treatment of nervous system aging. Chinese herbal medicines have a long history, featuring rich and safe ingredients, and have great potential for the development of anti-aging treatment. We searched the publications on PubMed with key words \u201canti-aging of the nervous system\u201d and \u201cChinese herbal medicine\u201d in recent 10\u00a0years, and found sixteen Chinese herbal medicines. Then by comparing their popularity of use as well as active components based on the research articles, five common Chinese herbal medicines namely Ginseng Radix, Lycii Fructus, Astragali Radix, Coptidis Rhizoma and Ginkgo Folium, were confirmed to be the most related to anti-nervous system aging and neural degenerative diseases. At the same time, the active ingredients, research models, action mechanisms and curative effects of these five common Chinese herbal medicines were reviewed. From the five common Chinese herbal medicines reviewed in this paper, many encouraging effects of Chinese herbal medicines on treating nervous system aging and related diseases were revealed and more potent herbs would be explored with the help of the proposed possible mechanisms.<\/jats:p>","DOI":"10.1177\/15333175231205445","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T04:11:40Z","timestamp":1696997500000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Anti-Aging of the Nervous System and Related Neurodegenerative Diseases With Chinese Herbal Medicine"],"prefix":"10.1177","volume":"38","author":[{"given":"Xiaohui","family":"Du","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China"},{"name":"Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, 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