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In this study, we investigated the role of Peripheral Blood Memory B cells (PBMBs) and their secreted Migration Inhibition Factor (MIF) in driving macrophage behavior in AD based on the scRNA-seq technique, immunofluorescence and flow cytometry. We discovered that MIF binds to the CD74-CD44 receptor complex on macrophages, influencing their behavior. The dysregulated macrophage response hampers the clearance of amyloid-beta (A\u03b2) plaques, exacerbating AD pathology. Targeting the MIF-CD74-CD44 signal pathway may hold therapeutic potential in modulating macrophage activity and mitigating neuroinflammation in AD. This study provides a further understanding of peripheral immune cells dysregulated in AD.<\/jats:p>","DOI":"10.1177\/15333175241238577","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T07:27:50Z","timestamp":1710574070000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Migration Inhibition Factor Secreted by Peripheral Blood Memory B Cells Binding to CD74-CD44 Receptor Complex Drives Macrophage Behavior in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3595-9783","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Clinical Medical College of Jinan University, Jinan University, Guangzhou, China"},{"name":"Department of Geriatric Neurology, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 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