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There is conflicting evidence regarding the association of peripheral TREM2 mRNA expression\/soluble TREM2 (the extracellular domain of TREM2) with cognitive function\/neuroinflammation in patients with AD. Herein, we studied the TREM2 and TREM2\n                    <jats:sub>alt<\/jats:sub>\n                    mRNA expression and their association with the cognitive performance in subjects with mild dementia due to AD and healthy controls. In a subgroup of patients with AD, magnetic resonance spectroscopy was used to measure the myo-inositol level in the posterior cingulate cortex, a surrogate marker for neuroinflammation. The results showed that increased TREM2 and TREM2\n                    <jats:sub>alt<\/jats:sub>\n                    mRNA expression is associated with AD pathogenesis at the mild dementia stage, thereby serving as a potential biomarker for early symptomatic stage of AD. TREM2 may exert protective effects on both cognition and central neuroinflammation.\n                  <\/jats:p>","DOI":"10.1177\/15333175241243183","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T10:42:50Z","timestamp":1712659370000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer\u2019s Disease and Reflect Central Neuroinflammation"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-8609","authenticated-orcid":false,"given":"Yi-Kuan","family":"Chiang","sequence":"first","affiliation":[{"name":"Division of General Neurology, Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, 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