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While monoclonal antibodies targeting A\u03b2 have shown cognitive benefits, safety concerns remain. Here, we introduce the Amytrapper catheter, a novel extracorporeal device developed by Recombinant Technologies to trap circulating A\u03b2 using a retro-inverso peptide conjugated to polyethylene glycol. Through in vivo experiments using a rat model of AD, we demonstrate significant reductions in blood A\u03b2 levels and behavioral improvements following Amytrapper catheter treatment. 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