{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:04:35Z","timestamp":1777381475599,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Creutzfeldt-Jakob disease (CJD) is a fatal prion disorder marked by rapidly progressive dementia and neuropsychiatric features. Epidemiological data in Latin America are limited, and no incidence studies exist in Mexico. This study sought to quantify CJD incidence in a neurological reference center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted at the National Institute of Neurology and Neurosurgery, Mexico City, during 2023-2024. Clinical and paraclinical findings were reviewed. Incidence was calculated per 1000 emergency visits, with relative risk (RR) and 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 19\u00a0003 patients, 15 fulfilled probable CJD criteria. Incidence was 0.55\/1000 in 2023 and 1.01\/1000 in 2024 (RR 1.83; 95% CI 0.63-5.35;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .309). Cognitive and behavioral symptoms predominated (psychosis in 68%). MRI revealed abnormalities in all cases, most often cortical ribboning (93%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This first incidence study highlights the presence of CJD in specialized Mexican centers, underscoring the need for systematic surveillance and improved diagnostic access.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15333175251391561","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T18:00:36Z","timestamp":1761415236000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of Sporadic Creutzfeldt-Jakob Disease in the Emergency Department"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5237-4682","authenticated-orcid":false,"given":"Ilse","family":"Murrieta-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0131-1095","authenticated-orcid":false,"given":"Daniel","family":"Garc\u00eda-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Ticehurst-Corona","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3907-7490","authenticated-orcid":false,"given":"Enrique","family":"Pi\u00f1a-Rosales","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-4058","authenticated-orcid":false,"given":"H\u00e9ctor","family":"T\u00e9llez-Lucero","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5561-2431","authenticated-orcid":false,"given":"Isaac","family":"Tetlalmatzi-Azuara","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-5160","authenticated-orcid":false,"given":"Juan Carlos","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"},{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-9941","authenticated-orcid":false,"given":"Mayela","family":"Rodr\u00edguez-Violante","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Dzul-Garcia","sequence":"additional","affiliation":[{"name":"Universidad Nacional Autonoma de Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1799-0277","authenticated-orcid":false,"given":"Ra\u00fal","family":"Medina-Rioja","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"},{"name":"Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30615-2"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02866081"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02870932"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63945-5.00001-5"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3839.388"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00497-y"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000251"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00659-0"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000196440.00297.67"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.46319"},{"key":"e_1_3_6_12_2","unstructured":"NORD Creudtzfeldt-Jakob Disease - NORD (National Organization for Rare Disorders) [Internet]. NORD (National Organization for Rare Disorders). NORD; 2015. https:\/\/rarediseases.org\/es\/rare-diseases\/creutzfeldt-jakob-disease\/. Accessed 30th November 2024."},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331907"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.24875\/GMM.M22000719"},{"key":"e_1_3_6_15_2","first-page":"89","article-title":"Enfermedades pri\u00f3nicas en M\u00e9xico: primer an\u00e1lisis bioinform\u00e1tico sobre la aplicaci\u00f3n de herramientas diagn\u00f3sticas y su repercusi\u00f3n en la predicci\u00f3n de supervivencia de pacientes con enfermedad de Creutzfeldt-Jakob entre 1990 y 2023","volume":"5","author":"Cruz-Lopez F","year":"2023","unstructured":"Cruz-Lopez F, Reyes-Ter\u00e1n G, Yescas-G\u00f3mez P, et al. Enfermedades pri\u00f3nicas en M\u00e9xico: primer an\u00e1lisis bioinform\u00e1tico sobre la aplicaci\u00f3n de herramientas diagn\u00f3sticas y su repercusi\u00f3n en la predicci\u00f3n de supervivencia de pacientes con enfermedad de Creutzfeldt-Jakob entre 1990 y 2023. 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