{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:18:46Z","timestamp":1779103126729,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004896","name":"Eisai Incorporated","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>The increasing incidence of Alzheimer\u2019s disease (AD) coupled with emerging diagnostics and treatments underscores the need for early detection of AD, yet identifying these individuals remains challenging. This US study sought to examine community-based physician attitudes regarding diagnosis and treatment of early AD (mild cognitive impairment [MCI] due to AD and mild AD). A total of 177 primary care physicians (PCPs) and 147 neurologists recruited through a national physician panel were surveyed about early AD diagnostic and treatment processes, and self-confidence in identifying and managing the condition. Physicians identified patient and family\/caregiver involvement as critical in triggering the diagnostic process. Patterns of use of neurocognitive assessments, structural imaging tests, and AD-specific biomarkers varied between PCPs and neurologists. Confidence diagnosing and managing early AD was a concern across specialties, although was greater among PCPs. Programs promoting awareness of early AD symptoms, and emerging technologies and treatments are critical to timely management.<\/jats:p>","DOI":"10.1177\/15333175261433309","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:33:33Z","timestamp":1778668413000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Community-Based Physician Attitudes Related to the Diagnosis and Treatment of Early Alzheimer\u2019s Disease in the United States"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-4113","authenticated-orcid":false,"given":"Timothy R.","family":"Juday","sequence":"first","affiliation":[{"name":"Eisai Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-9184","authenticated-orcid":false,"given":"Ashley","family":"Holub","sequence":"additional","affiliation":[{"name":"Analysis Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-9132","authenticated-orcid":false,"given":"Soeren","family":"Mattke","sequence":"additional","affiliation":[{"name":"University of Southern California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-7453","authenticated-orcid":false,"given":"Keith A.","family":"Betts","sequence":"additional","affiliation":[{"name":"Analysis Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie A.","family":"Kitchen","sequence":"additional","affiliation":[{"name":"Analysis Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-5170","authenticated-orcid":false,"given":"Hongjiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Analysis Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1992-1112","authenticated-orcid":false,"given":"Feride H.","family":"Frech","sequence":"additional","affiliation":[{"name":"Eisai Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9973-5039","authenticated-orcid":false,"given":"Ara S.","family":"Khachaturian","sequence":"additional","affiliation":[{"name":"Prevent Alzheimer\u2019s Disease 2020, Inc. (PAD 20\/20)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.306071"},{"key":"e_1_3_7_4_2","article-title":"More than Normal aging: understanding mild cognitive impairment","author":"Alzheimer\u2019s Association","year":"2022","unstructured":"Alzheimer\u2019s Association. More than Normal aging: understanding mild cognitive impairment. Alzheimer\u2019s Disease Facts and Figures. 2022; https:\/\/adrag.org\/wp-content\/uploads\/2024\/02\/alzheimers-facts-and-figures-1.pdf.","journal-title":"Alzheimer\u2019s Disease Facts and Figures"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.23"},{"key":"e_1_3_7_6_2","unstructured":"Alzheimer's Association. Special Report. On the Front Lines: Primary Care Physicians and Alzheimer\u2019s Care in America. 2020. https:\/\/www.alz.org\/getmedia\/a3df5a45-a254-4e49-b7c0-20b412715069\/alzheimers-facts-and-figures-special-report-2020.pdf"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-019-05013-7"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13244"},{"key":"e_1_3_7_9_2","unstructured":"Alzheimer\u2019s Association. Special report. American Perspectives on Early Detection of Alzheimer\u2019s Disease in the Era of Treatment. 2025. https:\/\/www.alz.org\/getmedia\/3d226bf2-0690-48d0-98ac-d790384f4ec2\/alzheimers-facts-and-figures-special-report.pdf"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.2217\/fnl-2023-0024"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.592302"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.36030"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-101"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14337"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988707311032"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40211-016-0185-y"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006148"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533317512470209"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-023-00504-6"},{"key":"e_1_3_7_21_2","first-page":"CD010783","article-title":"Mini\u2010Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)","volume":"3","author":"Arevalo\u2010Rodriguez I","year":"2015","unstructured":"Arevalo\u2010Rodriguez I, Smailagic N, i Figuls MR, et al. Mini\u2010Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI). Cochrane database of systematic reviews. 2015;3:CD010783.","journal-title":"Cochrane database of systematic reviews"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-015-0103-3"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/45368"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.09.011"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01314-6"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9016-3"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.focus.11.1.96"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.215"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.263195"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.06.006"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00400-6"},{"key":"e_1_3_7_33_2","unstructured":"Beta Amyloid Positron Emission Tomography in Dementia and Neurodegenerative Disease. https:\/\/www.cms.gov\/medicare-coverage-database\/view\/ncacal-decision-memo.aspx?proposed=N&ncaid=308"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1089\/pop.2023.0309"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.8392"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02869-z"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12756"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12081"},{"key":"e_1_3_7_39_2","first-page":"CD001190","article-title":"Donepezil for dementia due to Alzheimer\u2019s disease","volume":"6","author":"Birks JS","year":"2018","unstructured":"Birks JS, Harvey RJ. Donepezil for dementia due to Alzheimer\u2019s disease. Cochrane Database of systematic reviews. 2018;6:CD001190.","journal-title":"Cochrane Database of systematic reviews"},{"key":"e_1_3_7_40_2","unstructured":"Stiles MM Martin SI. Does treatment with donepezil improve memory for patients with mild cognitive impairment? 2006;55:435."},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220471"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051022-043645"},{"key":"e_1_3_7_43_2","unstructured":"U.S. Food and Drug Administration. FDA Converts Novel Alzheimer\u2019s Disease Treatment to Traditional Approval. https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-converts-novel-alzheimers-disease-treatment-traditional-approval"},{"key":"e_1_3_7_44_2","unstructured":"U.S. Food and Drug Administration. FDA approves treatment for adults with Alzheimer\u2019s disease. 2024."},{"key":"e_1_3_7_45_2","first-page":"27455","article-title":"Practical diagnosis and management of dementia due to Alzheimer\u2019s disease in the primary care setting: an evidence-based approach","volume":"15","author":"Geldmacher DS","year":"2013","unstructured":"Geldmacher DS, Kerwin DR. Practical diagnosis and management of dementia due to Alzheimer\u2019s disease in the primary care setting: an evidence-based approach. The primary care companion for CNS disorders. 2013;15:27455.","journal-title":"The primary care companion for CNS disorders"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58070906"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181a6bebc"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1994.tb138193.x"},{"key":"e_1_3_7_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2019.07.015"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15333175261433309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15333175261433309","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15333175261433309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:33:39Z","timestamp":1779100419000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15333175261433309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":48,"alternative-id":["10.1177\/15333175261433309"],"URL":"https:\/\/doi.org\/10.1177\/15333175261433309","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"15333175261433309"}}