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This study examined the influence of SDOH on early brain health, specifically its cognitive dimension, in Colombian individuals from the world\u2019s largest kindred with autosomal dominant AD (ADAD) caused by the\n                    <jats:italic toggle=\"yes\">PSEN1<\/jats:italic>\n                    E280A mutation. Participants included 86 mutation carriers and 71 non-carriers. Brain health was assessed using the BHA_CS index from the TabCAT battery, and perceived stress using the PSS-14. Carriers showed significantly lower brain health and higher perceived stress than non-carriers. Multiple regression analyses identified genetic status, age, education, and place of residence as significant predictors of brain health, with higher education and urban residence associated with better performance. These results demonstrate that SDOH contribute to early cognitive variability even decades before clinical onset in ADAD.\n                  <\/jats:p>","DOI":"10.1177\/15333175261492405","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:29:50Z","timestamp":1790101790000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Social Determinants and Brain Health in PSEN1 E280A Carriers vs Non-Carriers: A Colombian Cohort"],"prefix":"10.1177","volume":"41","author":[{"given":"C. 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