{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:58Z","timestamp":1792787698535,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"General Scientific Research Project of the Department of Education of Zhejiang Province","award":["Y202455543"],"award-info":[{"award-number":["Y202455543"]}],"id":[{"id":"https:\/\/ror.org\/05gj07w56","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease and atopic dermatitis may converge on shared immunoinflammatory pathways, but their molecular relationship remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We integrated differential expression, enrichment analysis, network prioritization, machine learning, external dataset assessment, and Mendelian randomization to identify shared molecular signatures and assess their causal relevance. Single-cell transcriptomics, cell-cell communication analysis, virtual knockout, and molecular simulation were further applied to define cell-type-specific signaling networks and evaluate drug-target interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Integrative transcriptomic analyses identified MYD88 and FGR as hub genes linking immune activation with structural regulation. Convergent evidence highlighted the IgSF CAM signaling pathway, suggesting that impaired cell adhesion and intercellular communication represent a common pathological feature of both diseases. Single-cell analyses revealed distinct microenvironmental signaling landscapes, characterized by NRG-ERBB4 activity in Alzheimer\u2019s disease and MIF-centered immune networks in atopic dermatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest potential shared immune-structural regulatory features between Alzheimer\u2019s disease and atopic dermatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15333175261495656","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:44:31Z","timestamp":1791557071000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-Scale Integrative Transcriptomic Analysis of Alzheimer\u2019s Disease and Atopic Dermatitis Reveals Shared Immune and Cellular Networks"],"prefix":"10.1177","volume":"41","author":[{"given":"Hongwei","family":"Liu","sequence":"first","affiliation":[{"name":"Taiyuan City Central Hospital"},{"name":"Xuanwu Hospital of Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxu","family":"Yin","sequence":"additional","affiliation":[{"name":"Taiyuan City Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinan","family":"Ye","sequence":"additional","affiliation":[{"name":"Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3032-1875","authenticated-orcid":false,"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Taizhou Municipal Hospital (Taizhou University Affiliated Municipal 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