{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:20Z","timestamp":1792787720890,"version":"4.5.0"},"reference-count":76,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81901084"],"award-info":[{"award-number":["81901084"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Affiliated Hospital of Yangzhou University","award":["YZ2024241"],"award-info":[{"award-number":["YZ2024241"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Alzheimers Dis Other Demen"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Vascular mild cognitive impairment (VaMCI) is an early stage of vascular dementia, yet its neuroimaging characteristics are not fully understood. This study examined alterations in structural-functional connectivity (SC\u2013FC) coupling and their relationships with cognition in young and middle-aged patients with VaMCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We acquired diffusion tensor imaging and resting-state functional MRI data from 83 young and middle-aged patients with VaMCI and 82 healthy controls (HCs). Based on the Brainnetome Atlas (BNA246), static and dynamic SC\u2013FC coupling metrics (Static Coupling, Dynamic Mean, Variance, Bias, and Probability) were calculated using a time point-by-time point edge-centric co-fluctuation analysis. Group differences in these metrics and their partial correlations with neuropsychological scores were assessed, with false discovery rate (FDR) correction applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with HCs, young and middle-aged patients with VaMCI exhibited significantly poorer performance in memory, language, and attention. At the regional level, Static Coupling, Bias, and Probability showed significant group differences, whereas Dynamic Mean and Variance did not. At the network level, significant differences in Static Coupling and Bias were found in the default mode network (DMN). In addition, the Probability metric in the left inferior parietal lobule (IPL) within the dorsal attention network (DAN) was negatively correlated with Verbal Fluency Test scores (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.414,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0001, FDR-corrected\n                      <jats:italic toggle=\"yes\">q<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Young and middle-aged patients with VaMCI present a multilevel profile of SC\u2013FC coupling alterations, along with impairments in memory, attention, and language. The DMN appears to be a key network showing SC\u2013FC coupling differences. The Probability metric in the left IPL within the DAN may represent a potential imaging correlate of language dysfunction and an exploratory region of interest for future network-based intervention research. These findings warrant further validation in larger, multicenter, longitudinal, and interventional cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15333175261495870","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:14:47Z","timestamp":1791580487000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Static and Dynamic Structure-function Coupling in Young and Middle-Aged Adults With Vascular Mild Cognitive Impairment: A BNA246 Atlas-Based Brain Network Study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6229-8248","authenticated-orcid":false,"given":"Teng","family":"Zhang","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Yangzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifang","family":"Gao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaji","family":"Tu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Yangzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Luo","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000034"},{"issue":"06","key":"e_1_3_5_4_2","first-page":"655","article-title":"Interpretation of the 2019 Chinese Guidelines for the Diagnosis and Management of Vascular Cognitive Impairment","volume":"49","author":"Song H","year":"2021","unstructured":"Song H, Sun D, Zhang JJ. Interpretation of the 2019 Chinese Guidelines for the Diagnosis and Management of Vascular Cognitive Impairment. Chinese Journal for Clinicians. 2021;49(06):655-7+61.","journal-title":"Chinese Journal for Clinicians"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000208"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0238-4"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009316"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.04.063"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221149937"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2204148"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.012"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2451-17.2018"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9372050"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70866"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaf163"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.036140"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873251324400"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70616"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012765"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2025.106297"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-025-01032-7"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01380.x"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70258"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000080"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-13813-7"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70205"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/03000605261431456"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08231-4"},{"key":"e_1_3_5_30_2","first-page":"\u25a0\u25a0\u25a0","article-title":"Group-common and individual-specific effects of structure-function coupling in human brain networks with graph neural networks","author":"Chen P","year":"2024","unstructured":"Chen P, Yang H, Zheng X, et al. Group-common and individual-specific effects of structure-function coupling in human brain networks with graph neural networks. bioRxiv. 2024;\u25a0\u25a0\u25a0:\u25a0\u25a0\u25a0.","journal-title":"bioRxiv"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.31083\/JIN47508"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63000-5"},{"key":"e_1_3_5_33_2","first-page":"\u25a0\u25a0\u25a0","article-title":"Dynamic functional connectivity to tile the spatiotemporal mosaic of brain states","volume":"2","author":"Van De Ville D","year":"2024","unstructured":"Van De Ville D, Li\u00e9geois R. Dynamic functional connectivity to tile the spatiotemporal mosaic of brain states. Imaging Neurosci (Camb). 2024;2:\u25a0\u25a0\u25a0.","journal-title":"Imaging Neurosci (Camb)"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2005531117"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00719-y"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.074"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2024.120902"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03466-x"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-005-0042-4"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70206"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw157"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2026.112149"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2024.103726"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.09.007"},{"issue":"35","key":"e_1_3_5_45_2","first-page":"2737","article-title":"Society of Neurology, Chinese Medical Association, and Writing Group of Chinese Guidelines for Diagnosis and Treatment of Vascular Cognitive Disorders (2019) Chinese Guidelines for Diagnosis and Treatment of Vascular Cognitive Disorders","volume":"99","author":"Subspecialty Group of Cognitive Disorders","unstructured":"Subspecialty Group of Cognitive Disorders. Society of Neurology, Chinese Medical Association, and Writing Group of Chinese Guidelines for Diagnosis and Treatment of Vascular Cognitive Disorders (2019) Chinese Guidelines for Diagnosis and Treatment of Vascular Cognitive Disorders. J National Medical Journal of China. \u25a0\u25a0\u25a0;99(35):2737-2744.","journal-title":"J National Medical Journal of China"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00131-X"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph120708198"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.12997\/jla.2021.10.1.88"},{"issue":"10","key":"e_1_3_5_49_2","first-page":"632","article-title":"Overview of the Research and Application of the Montreal Cognitive Assessment","volume":"35","author":"Chen N","year":"2009","unstructured":"Chen N, He L. Overview of the Research and Application of the Montreal Cognitive Assessment. Chinese Journal of Nervous and Mental Diseases. 2009;35(10):632-634.","journal-title":"Chinese Journal of Nervous and Mental Diseases"},{"issue":"37","key":"e_1_3_5_50_2","first-page":"2945","article-title":"Chinese Guidelines for Brief Cognition Tests in Diagnosing Dementia Disorders","volume":"96","author":"Tian JZ","year":"2016","unstructured":"Tian JZ, Xie HG, Qin B, et al. Chinese Guidelines for Brief Cognition Tests in Diagnosing Dementia Disorders. National Medical Journal of China. 2016;96(37):2945-2959.","journal-title":"National Medical Journal of China"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.10.1654"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2004.02.001"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2005.07.003"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4679(199611)52:6<651::AID-JCLP7>3.0.CO;2-N"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U"},{"issue":"4","key":"e_1_3_5_56_2","first-page":"191","article-title":"Investigation and significance of social functioning in the Beijing population","volume":"12","author":"Guan XT","year":"2005","unstructured":"Guan XT, Chen WH, Wang YL. Investigation and significance of social functioning in the Beijing population. J Chinese Journal of Neuroimmunology and Neurology. 2005;12(4):191-194.","journal-title":"J Chinese Journal of Neuroimmunology and Neurology"},{"issue":"25","key":"e_1_3_5_57_2","first-page":"5233","article-title":"A Cross-Sectional Survey of Neuropsychiatric Symptoms Among Community-Dwelling Older Adults With Normal Cognitive Function","volume":"8","author":"Xie HG","year":"2004","unstructured":"Xie HG, Wang LN, Yu X. A Cross-Sectional Survey of Neuropsychiatric Symptoms Among Community-Dwelling Older Adults With Normal Cognitive Function. J Chinese Journal of Tissue Engineering Research. 2004;8(25):5233-5235.","journal-title":"J Chinese Journal of Tissue Engineering Research"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3857"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq075"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25273"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.803504"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1162\/netn_a_00314"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422487112"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2024.12.016"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijchp.2024.100508"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2026.121888"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11111534"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2025.111311"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220837"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.672665"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0307-25.2025"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.890483"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-022-02510-0"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2013.06.005"}],"container-title":["American Journal of Alzheimer's Disease &amp; Other Dementias\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15333175261495870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15333175261495870","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15333175261495870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:54:16Z","timestamp":1791885256000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15333175261495870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":76,"alternative-id":["10.1177\/15333175261495870"],"URL":"https:\/\/doi.org\/10.1177\/15333175261495870","relation":{},"ISSN":["1533-3175","1938-2731"],"issn-type":[{"value":"1533-3175","type":"print"},{"value":"1938-2731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"article-number":"15333175261495870"}}