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PC ae C38:1 was the only lipid associated with ordinal group score after false discovery rate correction (\u03b2 = 0.231; q = 0.021). The categorical group omnibus test also met the corrected threshold (q = 0.043). Twenty lipid\u2013CSF A\u03b242 associations were identified before group adjustment, compared with none afterward in the original linear models. Rank-based models with categorical adjustment identified two A\u03b242 associations. Sex hormone-binding globulin (SHBG) was associated with 35 lipids under conventional inference and 32 under HC3 inference. No module met the corrected threshold for group score or group-adjusted A\u03b242. These cross-sectional findings offer preliminary evidence of lipid associations with group status and SHBG, with A\u03b242 results varying across models.<\/jats:p>","DOI":"10.1177\/15333175261498635","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:35:01Z","timestamp":1792330501000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Serum Lipids With Clinical\u2013Amyloid Groups, CSF A\u03b242, and SHBG in ADNI-1"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5405-0252","authenticated-orcid":false,"given":"Leilei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Encephalopathy (Ward 2), Xi\u2019an Hospital of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Xi\u2019an Gaoxin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Encephalopathy (Ward 2), Xi\u2019an Hospital of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Encephalopathy (Ward 2), Xi\u2019an Hospital of Traditional Chinese Medicine"},{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Encephalopathy (Ward 2), Xi\u2019an Hospital of Traditional Chinese Medicine"},{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-017-0073-9"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.010"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.01.020"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2017.140"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-025-01778-5"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3466"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01359-7"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1430465"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.014"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.08.003"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2019.07.002"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105826"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2025.e00756"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaf363"},{"key":"e_1_3_9_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251415349"},{"key":"e_1_3_9_20_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.092593"},{"key":"e_1_3_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.10.001"},{"key":"e_1_3_9_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27266"},{"key":"e_1_3_9_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-025-01365-y"},{"key":"e_1_3_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.263"},{"key":"e_1_3_9_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cb3e25"},{"key":"e_1_3_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_9_27_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2018.2"},{"key":"e_1_3_9_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.43.11.2412-a"},{"key":"e_1_3_9_29_2","unstructured":"Biomarkers Consortium. 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