{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:06Z","timestamp":1787019246768,"version":"build-2736575974"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>The acute Charcot foot complicates distal symmetrical neuropathy but is remarkably rare. This article reviews the multiple processes that may complicate both diabetes and neuropathy and might, in turn, explain the association of features that are typical of this disorder: osteolysis, vascular calcification in association with intact lower limb blood flow, and uncontrolled inflammation. Specifically, it is suggested that the disorder arises because of abnormal expression of the nuclear transcription factor, NFkappaB, in diabetic neuropathy and that this is further enhanced at the onset of the acute arthropathy as a result of the release of proinflammatory cytokines, such as tumor necrosis factor-\u03b1 and interleukin-1. These proinflammatory cytokines and RANKL may then enter a cycle of mutual augmentation, and this is a factor that underlies the continuing inflammation that characterizes the disorder. If this hypothesis is confirmed, it would suggest the option of new effective treatments for this sometimes devastating disorder.<\/jats:p>","DOI":"10.1177\/1534734605280447","type":"journal-article","created":{"date-parts":[[2005,8,11]],"date-time":"2005-08-11T21:10:14Z","timestamp":1123794614000},"page":"133-137","source":"Crossref","is-referenced-by-count":33,"title":["Abnormalities of Vasomotor Regulation in the Pathogenesis of the Acute Charcot Foot of Diabetes Mellitus"],"prefix":"10.1177","volume":"4","author":[{"given":"William J.","family":"Jeffcoate","sequence":"first","affiliation":[{"name":"Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"atypb1","first-page":"1085","volume":"45","author":"Rajbhandari SM","year":"2001","journal-title":"Diabetologia"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00233.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-183108150-00004"},{"key":"atypb4","first-page":"161","volume":"1","author":"Charcot J-M.","year":"1868","journal-title":"Arch Physiol Norm Pathol"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1936.00170060069004"},{"key":"atypb6","first-page":"305","volume":"6","author":"Charcot J-M","year":"1883","journal-title":"Arch Neurologie"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1991.tb01517.x"},{"key":"atypb8","unstructured":"Anonymous. Berliner medicinische Gesellschaft. Sitzung vom 17 November 1886. Berliner Klinische Wonchenschr 1886."},{"key":"atypb9","unstructured":"Knaggs RI. Charcot joints. In: Knaggs RI. Inflammatory and toxic disorders of bone. Bristol, UK: John Wright &! Sons; 1926. p. 105-119."},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(97)00080-9"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197205000-00006"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6320.928"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05494-0"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000149165.99974.12"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020775"},{"key":"atypb16","first-page":"631","volume":"86","author":"Browner WS","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1477-5"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1985.tb00683.x"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(94)90058-2"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1995.tb00389.x"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.5.827"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01510.x"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.86B3.14593"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.01.031"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.4.855"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.12.2792"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000112023.62695.7f"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200207000-00011"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10270"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3953"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00494-X"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10119"},{"key":"atypb33","author":"Jeffcoate WJ","journal-title":"Lancet"},{"issue":"1","key":"atypb34","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1002\/dmrr.451","volume":"20","author":"Sanders LJ","year":"2004","journal-title":"Diabet Metab Res Rev"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.3.249"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2002.21"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-003-0085-6"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033453640"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100008"},{"key":"atypb40","volume-title":"3rd Joint Meeting of the Diabetic Foot Study Group and Neurodiab","author":"Kotuhova Y"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734605280447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734605280447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:06:17Z","timestamp":1777457177000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1534734605280447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1177\/1534734605280447"],"URL":"https:\/\/doi.org\/10.1177\/1534734605280447","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}