{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:07:16Z","timestamp":1777712836767,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>Pyoderma gangrenosum (PG) is an inflammatory ulcerative condition of unknown etiology. An autoimmune mechanism including immune complex\u2014mediated neutrophilic vascular reactions has been suggested. The role of tumor necrosis factor (TNF) in PG remains unclear. Evidence supports the idea that TNF plays a role in chronic inflammation and migration of neutrophils to these lesions. PG is frequently associated with various diseases, but up to 50% of cases are idiopathic. There are several reports describing the successful use of infliximab\u2122 (Remicade \u00ae , Centocor, Inc, Horsham, Pa), a chimeric antitumor necrosis factor \u03b1 monoclonal antibody, in the treatment of inflammatory bowel disease\u2014 associated PG, but there have been few reported cases of infliximab in the treatment of idiopathic PG. The authors present a dramatic improvement in 4 cases of idiopathic PG of the lower leg treated with infliximab.<\/jats:p>","DOI":"10.1177\/1534734607300912","type":"journal-article","created":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T23:37:15Z","timestamp":1181345835000},"page":"108-113","source":"Crossref","is-referenced-by-count":22,"title":["Improvement of Idiopathic Pyoderma Gangrenosum During Treatment With Anti-Tumor Necrosis Factor Alfa Monoclonal Antibody"],"prefix":"10.1177","volume":"6","author":[{"given":"Valentina","family":"Dini","sequence":"first","affiliation":[{"name":"Wound Healing Research Unit, Department of Dermatology,\rUniversity of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Wound Healing Research Unit, Department of Dermatology,\rUniversity of Pisa, Pisa, Italy,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MariaStefania","family":"Bertone","sequence":"additional","affiliation":[{"name":"Wound Healing Research Unit, Department of Dermatology,\rUniversity of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Talarico","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Pisa, Pisa,\rItaly"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bombardieri","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Pisa, Pisa,\rItaly"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Barachini","sequence":"additional","affiliation":[{"name":"Wound Healing Research Unit, Department of Dermatology,\rUniversity of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734603260250"},{"issue":"3","key":"atypb2","first-page":"119","volume":"13","author":"Choucair MM","year":"2001","journal-title":"Wounds"},{"key":"atypb3","unstructured":"Burns T., Breathnach S., Cox N., Griffiths C. Pyoderma gangrenosum. In: Blackwell Science , editor. Rook's text book of dermatology. Oxford (UK): Blackwell Science; 2005. p. 49.36-49.39."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.006"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02184.x"},{"key":"atypb6","first-page":"116","volume":"3","author":"Provost TT","year":"2003","journal-title":"Adv Stud Med"},{"key":"atypb7","unstructured":"Wolff K., Stingl G. Pyoderma gangrenosum. In: Freedberg IM, Eisen AZ, Wolff K, Austen FK, editors. Fitzpatrick's dermatology in general medicine. 5th ed. 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