{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:07:25Z","timestamp":1777712845653,"version":"3.51.4"},"reference-count":62,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>Selective use of systemic hyperbaric oxygen therapy (HBOT) is a treatment that deserves further study and analysis. The current situation in the United Kingdom (UK) is discussed in relation to available evidence and practices elsewhere. It would appear that there is increasing evidence that HBOT could benefit many patients and health care budgets through improved clinical efficacy and cost-efficiency in the treatment of specific conditions, notably nonhealing diabetic ulceration of the lower limbs. This is not only disabling, it may lead to amputation. It is also a financial burden to patients and health service providers. In the UK, it is estimated that chronic wound care costs more than \u00a31 billion a year, with diabetic ulceration accounting for a substantial part of that staggering sum. It has been said repeatedly, and quite correctly, that there is insufficient good-quality evidence upon which a properly informed decision may be made on the contribution HBOT might make to alleviate that situation. It is intriguing that no determined effort is apparent that would seek to settle the issue by encouraging and facilitating appropriately designed and conducted randomized controlled trials to assess the actual effects of this treatment. Indeed, a proposed government research initiative appears to have been cancelled. Is lack of research preventing provision of HBOT?<\/jats:p>","DOI":"10.1177\/1534734607304626","type":"journal-article","created":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T17:03:05Z","timestamp":1191258185000},"page":"130-138","source":"Crossref","is-referenced-by-count":10,"title":["The Clinical and Economic Potential of Hyperbaric Oxygen Therapy in the Treatment of Diabetic Ulceration and Other Conditions"],"prefix":"10.1177","volume":"6","author":[{"given":"Grant","family":"McMillan","sequence":"first","affiliation":[{"name":"Independent Practice in Occupational Medicine, Alverstoke,\rHants, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Glover","sequence":"additional","affiliation":[{"name":"Hyperbaric Medicine Unit, Royal Hospital Haslar, Gosport,\rHampshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2006.78"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7330.160"},{"key":"atypb3","volume-title":"European Committee for Hyperbaric Medicine: 7th European Consensus Conference on Hyperbaric Medicine","author":"Mathieu D.","year":"2004"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe020103"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013121"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp020104"},{"issue":"13","key":"atypb7","volume":"2","author":"Dent T.","year":"2002","journal-title":"STEER: succinct and timely evaluated reviews"},{"key":"atypb8","volume-title":"Hyperbaric oxygen therapy policy revision \u2014 Final 31\/5\/01 [cited 14 May 2007]","author":"NHIC Medicare B, California, Update to HBO Therapy Services","year":"2001"},{"key":"atypb9","volume-title":"Medicare benefits schedule, 1 Nov 2004 [cited 14 May 2007]","author":"Australian Government, Department of Health and Ageing."},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/00063110-200402000-00009"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2003.10.010"},{"issue":"1","key":"atypb12","first-page":"97","volume":"75","author":"Geraci G.","year":"2004","journal-title":"Ann Ital Chir"},{"issue":"28","key":"atypb13","first-page":"2336","volume":"101","author":"Stenberg AE","year":"2004","journal-title":"Lakartidningen"},{"issue":"6","key":"atypb14","first-page":"437","volume":"32","author":"Escobar SJ","year":"2005","journal-title":"Undersea Hyperb Med"},{"issue":"10","key":"atypb15","first-page":"471","volume":"95","author":"Erttmann M.","year":"1992","journal-title":"Unfallchirug"},{"issue":"6","key":"atypb16","first-page":"381","volume":"72","author":"Kohshi K.","year":"2005","journal-title":"Mt Sinai J Med"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/000313480507100210"},{"issue":"2","key":"atypb18","first-page":"91","volume":"27","author":"Chen CE","year":"2004","journal-title":"Chang Gung Med J"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00117.x"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00388.x"},{"issue":"3","key":"atypb21","first-page":"175","volume":"30","author":"Wreford-Brown CE","year":"2003","journal-title":"Undersea Hyperb Med"},{"key":"atypb22","volume-title":"Interventions for replacing missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants (Cochrane Review)","author":"Coulthard P."},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.09.006"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.02.017"},{"issue":"2","key":"atypb25","first-page":"159","volume":"3","author":"Donovan DJ","year":"2005","journal-title":"Spine"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000236004.95384.5b"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.11.004"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00491-5"},{"key":"atypb29","first-page":"226","volume":"48","author":"Wang J.","year":"2002","journal-title":"J Postgrad Med"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1097\/00042752-200205000-00001"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1097\/00042752-200305000-00003"},{"issue":"2","key":"atypb32","first-page":"135","volume":"30","author":"Germain G.","year":"2003","journal-title":"Undersea Hyperb Med"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005005.pub2"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200535090-00001"},{"key":"atypb35","unstructured":"The management of patients with chronic venous leg ulcer\n\t\t\t\t. 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