{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:08:39Z","timestamp":1777712919886,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,5,19]],"date-time":"2008-05-19T00:00:00Z","timestamp":1211155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>The Difoprev system constituted by a sock loaded with nanocapsules containing a hydrating agent in the diabetic foot is tested. A total of 30 neuropathic outpatients with foot anhydrosis were randomized into group A, treated with the application of the sock with the nanocapsules, and group B wearing only the socks without the nanocapsules. Patients were blindly evaluated with a clinical score, hygrometry, transepidermal water loss, skin temperature, and skin hardness at baseline and after 6 weeks. No difference between the groups emerged at baseline. Although group B showed no changes at the end of the treatment, group A significantly ( P &lt; .05) improved in all the parameters evaluated. No adverse events were recorded in both groups during the study. The use of hydrating agents carried by nanocapsules-loaded socks is safe and effective for the neuropathic diabetic foot.<\/jats:p>","DOI":"10.1177\/1534734608318138","type":"journal-article","created":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T00:44:20Z","timestamp":1211244260000},"page":"82-87","source":"Crossref","is-referenced-by-count":10,"title":["Use of Nanotechnology-Designed Footsock in the Management of Preulcerative Conditions in the Diabetic Foot: Results of a Single, Blind Randomized Study"],"prefix":"10.1177","volume":"7","author":[{"given":"Banchellini","family":"Elisa","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic\rFoot Section, University of Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macchiarini","family":"Silvia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic\rFoot Section, University of Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dini","family":"Valentina","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dermatologic Clinic University\rof Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizzo","family":"Loredana","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic\rFoot Section, University of Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tedeschi","family":"Anna","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic\rFoot Section, University of Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scatena","family":"Alessia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic\rFoot Section, University of Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goretti","family":"Chiara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic\rFoot Section, University of Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Campi","family":"Fabrizio","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic\rFoot Section, University of Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romanelli","family":"Marco","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dermatologic Clinic University\rof Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Piaggesi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic\rFoot Section, University of Pisa,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,5,19]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1479-666X(07)80007-2","volume":"5","author":"Diamant AL","year":"2007","journal-title":"Surgeon"},{"key":"atypb2","first-page":"18","volume":"50","author":"Prompers L.","year":"2007","journal-title":"Baseline results from the Eurodiale study. 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