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Since the introduction of the homocysteine theory more than 30 years ago, considerable evidence has demonstrated hyperhomocysteinemia to be an independent risk factor for venous and arterial thrombosis, atherosclerosis and cardiovascular disease. Although any cause\u2014effect relationship remains to be determined, hyperhomocysteinemia as a risk factor for these events suggests that elevated levels of homocysteine may also be a marker of chronic lower limb ulceration. This review addresses the metabolism of homocysteine, mechanisms of vascular injury, a role for hyperhomocysteinemia in lower extremity wounds and possible means of treatment.<\/jats:p>","DOI":"10.1177\/1534734608322490","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:48:12Z","timestamp":1219970892000},"page":"126-136","source":"Crossref","is-referenced-by-count":13,"title":["Hyperhomocysteinemia and Lower Extremity Wounds"],"prefix":"10.1177","volume":"7","author":[{"given":"Elissa M.","family":"Schwartzfarb","sequence":"first","affiliation":[{"name":"Departments of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Departments of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, 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