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Inoculation commonly follows minor trauma, predominantly to the foot and hence is seen more among the barefoot-walking populations, common among adult males aged 20 to 50 years. The hallmark triad of the disease includes tumefaction, fistulization of the abscess, and extrusion of colored grains. The color of these extruded grains in the active phase of the disease offers a clue to diagnosis. Radiology, ultrasonology, cytology, histology, immunodiagnosis, and culture are tools used in diagnosis. Recently, DNA sequencing has also been used successfully. Though both infections manifest with similar clinical findings, Actinomycetoma has a rapid course and can lead to amputation or death secondary to systemic spread. However, actinomycetomas are more responsive to antibiotics, whereas eumycetomas require surgical excision in addition to antifungals. Complications include secondary bacterial infections that can progress to full-blown bacteremia or septicemia, resulting in death. With extremely disfiguring sequelae, following the breakdown of the nodules and formation of discharging sinuses, it poses a therapeutic challenge.<\/jats:p>","DOI":"10.1177\/1534734612438549","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T20:27:05Z","timestamp":1329251225000},"page":"31-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["The Madura Foot"],"prefix":"10.1177","volume":"11","author":[{"given":"Sandhya","family":"Venkatswami","sequence":"first","affiliation":[{"name":"Sri Ramachandra University, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anandan","family":"Sankarasubramanian","sequence":"additional","affiliation":[{"name":"Sri Ramachandra University, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobana","family":"Subramanyam","sequence":"additional","affiliation":[{"name":"Sri 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