{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:30Z","timestamp":1787019270328,"version":"build-2736575974"},"reference-count":76,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T00:00:00Z","timestamp":1340236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>Extremity injury and contamination as consequence are features of high-energy wounding. A leading cause of disability and the commonest cause of late complications, prevention of wound infection determines the ultimate outcome in these populations. Multiple variables influence the development of infection, one of which is the dressing used on the wound. Antiseptic-soaked gauze dressings feature in the early management of limb trauma despite a lack of evidence to support this. Iodine and chlorhexidine are ubiquitous in other aspects of health care however, and a plethora of studies detail their role in skin antisepsis, the recommendations from which are often anecdotally applied to acute wounding. To contextualize the role for antiseptic dressing use in acute, significant limb injury this review explores the evidence for the use of chlorhexidine and iodine in skin antisepsis. The paucity of experimental data available for antiseptic use in early wound management and the need for further research to address this evidence void is highlighted.<\/jats:p>","DOI":"10.1177\/1534734612450589","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T21:11:19Z","timestamp":1340399479000},"page":"213-223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Limb Wounding and Antisepsis"],"prefix":"10.1177","volume":"11","author":[{"given":"William G. P.","family":"Eardley","sequence":"first","affiliation":[{"name":"Royal Centre for Defence Medicine, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Watts","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Laboratory, Salisbury, Wiltshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon C.","family":"Clasper","sequence":"additional","affiliation":[{"name":"Royal Centre for Defence Medicine, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,6,21]]},"reference":[{"key":"bibr1-1534734612450589","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e31818e43dd"},{"key":"bibr2-1534734612450589","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182218c99"},{"key":"bibr3-1534734612450589","first-page":"16","volume":"49","author":"Robson MC","year":"2003","journal-title":"Ostomy Wound Manage"},{"key":"bibr4-1534734612450589","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000057076.71217.B2"},{"key":"bibr5-1534734612450589","volume-title":"Standards for the Management of Open Fractures of the Lower Limb","author":"Nanchahal J","year":"2009"},{"key":"bibr6-1534734612450589","volume-title":"Advanced Trauma Life Support for Doctors","author":"American College of Surgeons Committee on Trauma","year":"2008","edition":"8"},{"key":"bibr7-1534734612450589","volume-title":"Emergency War Surgery","author":"The United States Department of Defence","year":"2004","edition":"3"},{"key":"bibr8-1534734612450589","volume-title":"War Surgery Field Manual","author":"Husum H","year":"1995","edition":"1"},{"key":"bibr9-1534734612450589","first-page":"225","volume-title":"War Surgery","volume":"2009","author":"Giannou C","edition":"1"},{"key":"bibr10-1534734612450589","volume-title":"War Wounds of Limbs: Surgical Management","author":"Coupland RM","year":"2008","edition":"1"},{"key":"bibr11-1534734612450589","unstructured":"Sibbald RG, Leaper DJ, Queen D. 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