{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:29:51Z","timestamp":1792657791438,"version":"4.5.0"},"reference-count":80,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>The manner in which high-energy transfer limb injuries are dressed can alter the wound environment through manipulation of the bacterial burden, thus minimizing tissue degradation and influencing healing potential. Infection is the principal complication of such wounds, and antiseptic soaked gauze is accepted in early coverage of extremity wounds despite a lack of evidence to support this practice. There has been resurgence in the use of silver in acute wounds, through dressings manipulated to deliver sustained elemental silver to the wound interface. In vitro and in vivo experimentation of silver dressings are characterized however by methodological compromise, primarily through lack of similarity of models to the physiology of the healing wound. Results from in vitro studies caution against the use of silver because of evidence of cytotoxicity, but this is not reproduced in in vivo or clinical experimentation, leading to ambiguity. Review of silver dressing application in burns and chronic wound studies fails to support its use over other dressing systems. Similarly, evidence for the use of silver in acute limb wounds is lacking. This article provides a comprehensive overview of the use of silver dressings in acute wound care and highlights in particular the paucity of evidence regarding its routine use in extremity injury.<\/jats:p>","DOI":"10.1177\/1534734612457028","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T09:12:52Z","timestamp":1348477972000},"page":"201-212","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Extremity Trauma, Dressings, and Wound Infection"],"prefix":"10.1177","volume":"11","author":[{"given":"William G. P.","family":"Eardley","sequence":"first","affiliation":[{"name":"Royal Centre for Defence Medicine, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Watts","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Laboratory, Salisbury, Wiltshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon C.","family":"Clasper","sequence":"additional","affiliation":[{"name":"Royal Centre for Defence Medicine, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,9,24]]},"reference":[{"key":"bibr1-1534734612457028","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201102001-00002"},{"key":"bibr2-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1086\/520029"},{"key":"bibr3-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318221181d"},{"key":"bibr4-1534734612457028","volume-title":"Standards for the Management of Open Fractures of the Lower Limb","author":"Nanchahal J","year":"2009"},{"key":"bibr5-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e31818e43dd"},{"key":"bibr6-1534734612457028","unstructured":"World Health Organization. World Health Day 2011: Combat Antimicrobial Resistance. Geneva, Switzerland: WHO; 2011. http:\/\/www.who.int\/world-health-day\/2011\/WHD201_FS_EN.pdf. Accessed February 16, 2012."},{"key":"bibr7-1534734612457028","volume-title":"Advanced Trauma Life Support for Doctors","author":"American College of Surgeons Committee on Trauma","year":"2008","edition":"8"},{"key":"bibr8-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000057076.71217.B2"},{"key":"bibr9-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005082.pub2"},{"key":"bibr10-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.007"},{"key":"bibr11-1534734612457028","unstructured":"Smith & Nephew. Acticoat\n                      \u2122\n                      Antimicrobial barrier dressing. http:\/\/global.smith-nephew.com\/master\/ACTICOAT_27517.htm. Accessed February 28, 2012."},{"key":"bibr12-1534734612457028","unstructured":"British National Formulary. A5.3.3 silver. http:\/\/bnf.org\/bnf\/bnf\/current\/202270.htm. Accessed February 28, 2012."},{"key":"bibr13-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1136\/dtb.2010.02.0014"},{"key":"bibr14-1534734612457028","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2002.11.4.26389"},{"key":"bibr15-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1136\/fn.83.2.F158"},{"key":"bibr16-1534734612457028","first-page":"193","volume":"131","author":"Schneider G","year":"1984","journal-title":"Can Med Assoc J"},{"key":"bibr17-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(99)00108-4"},{"key":"bibr18-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(99)00116-3"},{"key":"bibr19-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1968.01330200022004"},{"key":"bibr20-1534734612457028","first-page":"95","volume":"57","author":"Moyer CA","year":"1965","journal-title":"J Natl Med Assoc"},{"key":"bibr21-1534734612457028","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2001.6.Sup1.12619"},{"key":"bibr22-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(02)00200-1"},{"key":"bibr23-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.06.010"},{"key":"bibr24-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00683.x"},{"key":"bibr25-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.10308.x"},{"key":"bibr26-1534734612457028","doi-asserted-by":"publisher","DOI":"10.2147\/nano.2006.1.4.441"},{"key":"bibr27-1534734612457028","unstructured":"Identifying criteria for wound infection: position statement. http:\/\/ewma.org\/fileadmin\/user_upload\/EWMA\/pdf\/Position_Documents\/2005__Wound_Infection_\/English_pos_doc_final.pdf. Accessed July 21, 2012."},{"key":"bibr28-1534734612457028","first-page":"16","volume":"49","author":"Robson MC","year":"2003","journal-title":"Ostomy Wound Manage"},{"key":"bibr29-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpsurg.2007.07.001"},{"key":"bibr30-1534734612457028","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2004.13.Sup1.12535"},{"key":"bibr31-1534734612457028","first-page":"910686","volume":"2010","author":"Lansdown AB","year":"2010","journal-title":"Adv Pharmacol Sci"},{"key":"bibr32-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(04)90000-9"},{"key":"bibr33-1534734612457028","first-page":"1S","volume":"50","author":"Ovington LG","year":"2004","journal-title":"Ostomy Wound Manage"},{"key":"bibr34-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-196905000-00002"},{"key":"bibr35-1534734612457028","unstructured":"Silverlon [product literature]. http:\/\/silverlon.com\/Clinical-studies"},{"key":"bibr36-1534734612457028","unstructured":"3M\n                      \u2122\n                      Tegaderm\n                      \u2122\n                      Ag mesh. The power of silver: product monograph. http:\/\/multimedia.3m.com\/mws\/mediawebserver?mwsId=SSSSSu7zK1fslxtUm8_1o8_xev7qe17zHvTSevTSeSSSSSS-&fn=70-2009-7137-5.pdf. Accessed February 29, 2012."},{"key":"bibr37-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2003.08.032"},{"key":"bibr38-1534734612457028","first-page":"21","volume":"15","author":"Wilkinson JM","year":"2004","journal-title":"Med Device Technol"},{"key":"bibr39-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130409.x"},{"key":"bibr40-1534734612457028","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2003.12.Sup4.12215"},{"key":"bibr41-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1053\/ic.1998.v26.a93527"},{"key":"bibr42-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(99)70055-6"},{"key":"bibr43-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199905000-00006"},{"key":"bibr44-1534734612457028","unstructured":"Smith & Nephew. ACTICOAT\u2122\/ACTICOAT 7 clinical evidence file http:\/\/wound.smith-nephew.com\/uk\/Home.asp. Accessed July 21, 2012."},{"key":"bibr45-1534734612457028","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2003.12.3.26477"},{"key":"bibr46-1534734612457028","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2003.12.8.26526"},{"key":"bibr47-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(03)00046-9"},{"key":"bibr48-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2003.09.008"},{"key":"bibr49-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2004.02916.x"},{"key":"bibr50-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2003.09.030"},{"key":"bibr51-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00190.x"},{"key":"bibr52-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2004.11732656"},{"key":"bibr53-1534734612457028","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2011.626538"},{"key":"bibr54-1534734612457028","doi-asserted-by":"publisher","DOI":"10.2478\/s13382-011-0041-z"},{"key":"bibr55-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.06.014"},{"key":"bibr56-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.05.003"},{"key":"bibr57-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/5\/4\/044103"},{"key":"bibr58-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2009.11.016"},{"key":"bibr59-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.085"},{"key":"bibr60-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1021\/nn800596w"},{"key":"bibr61-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46124-0"},{"key":"bibr62-1534734612457028","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11082864"},{"key":"bibr63-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2007.00316.x"},{"key":"bibr64-1534734612457028","first-page":"64","volume":"11","author":"Burrell RE","year":"1999","journal-title":"Wounds"},{"key":"bibr65-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000150298.57472.26"},{"key":"bibr66-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2005.05.002"},{"key":"bibr67-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1097\/01.bcr.0000176879.27535.09"},{"key":"bibr68-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.01.024"},{"key":"bibr69-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2008.05.020"},{"key":"bibr70-1534734612457028","first-page":"238","volume":"26","author":"Supp AP","year":"2005","journal-title":"J Burn Care Rehabil"},{"key":"bibr71-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.09.020"},{"key":"bibr72-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002106.pub3"},{"key":"bibr73-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.04.008"},{"key":"bibr74-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.06.020"},{"key":"bibr75-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006478.pub2"},{"key":"bibr76-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2008.02534.x"},{"key":"bibr77-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.10.1297"},{"key":"bibr78-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2007.03.024"},{"key":"bibr79-1534734612457028","doi-asserted-by":"publisher","DOI":"10.1177\/1534734606295140"},{"key":"bibr80-1534734612457028","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2006.15.7.26951"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734612457028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1534734612457028","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734612457028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:02:17Z","timestamp":1777456937000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1534734612457028"}},"subtitle":["Should Every Acute Limb Wound Have a Silver Lining?"],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1177\/1534734612457028"],"URL":"https:\/\/doi.org\/10.1177\/1534734612457028","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}