{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:12:55Z","timestamp":1777713175262,"version":"3.51.4"},"reference-count":84,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T00:00:00Z","timestamp":1351555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Chronic wounds remain a major challenge in modern medicine and represent a significant health care burden. Several treatments have been suggested, but without a full understanding of the exact mechanism by which chronic wound occurs. Numerous studies have shown that mesenchymal stem cells\/multipotent mesenchymal stromal cells (MSCs) may have therapeutic potential in healing cutaneous chronic wounds through various mechanisms. So far, a series of hypotheses have been proposed, but a holistic image of them is lacking. This review provides a systematic analysis of recent research in animal models and preclinical or clinic trails to evaluate the potential role of MSCs in chronic cutaneous wound healing. Most important, we highlight how mesenchymal stem cells could potentially revolutionize our approach to treating cutaneous chronic wounds. Special attention should be focused on ongoing research regarding the challenges in using and prospects of MSCs in clinical settings.<\/jats:p>","DOI":"10.1177\/1534734612463935","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T16:17:09Z","timestamp":1354724229000},"page":"244-253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Mesenchymal Stem Cells\/Multipotent Mesenchymal Stromal Cells (MSCs)"],"prefix":"10.1177","volume":"11","author":[{"given":"Ji-Ping","family":"Zou","sequence":"first","affiliation":[{"name":"Guangzhou General Hospital of Guangzhou Command, GuangDong, The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area, PLA, P R China"},{"name":"Third Military Medical University of PLA, ChongQing, P R China"},{"name":"General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P R China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Huang","sequence":"additional","affiliation":[{"name":"General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P R China"},{"name":"Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, P R China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[{"name":"Guangzhou General Hospital of Guangzhou Command, GuangDong, The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area, PLA, P R China"},{"name":"General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P R China"},{"name":"Southern Medical University, Guangzhou, P R China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine, Ministry of Education, Guangzhou, P R China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Guangzhou General Hospital of Guangzhou Command, GuangDong, The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area, PLA, P R China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Bing","family":"Fu","sequence":"additional","affiliation":[{"name":"General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P R China"},{"name":"Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, P R China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Guangzhou General Hospital of Guangzhou Command, GuangDong, The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area, PLA, P R China"},{"name":"Southern Medical University, Guangzhou, P R China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,30]]},"reference":[{"key":"bibr1-1534734612463935","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0730"},{"key":"bibr2-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2010.00666.x"},{"key":"bibr3-1534734612463935","first-page":"22","volume":"6","author":"Fan WPL","year":"2010","journal-title":"Wounds UK"},{"key":"bibr4-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2011.0297"},{"key":"bibr5-1534734612463935","doi-asserted-by":"publisher","DOI":"10.3184\/003685010X12708175591515"},{"key":"bibr6-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.22-5-812"},{"key":"bibr7-1534734612463935","first-page":"134","volume":"27","author":"Vojtassak J","year":"2006","journal-title":"Neuro Endocrinol Lett"},{"key":"bibr8-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181c722bb"},{"key":"bibr9-1534734612463935","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.7.1036"},{"key":"bibr10-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00306-4"},{"key":"bibr11-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32169"},{"key":"bibr12-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"bibr13-1534734612463935","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2008.17.9.30937"},{"key":"bibr14-1534734612463935","first-page":"1159","volume":"34","author":"Rodriguez PG","year":"2008","journal-title":"Dermatol Surg"},{"key":"bibr15-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700701"},{"key":"bibr16-1534734612463935","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.3.1848"},{"key":"bibr17-1534734612463935","first-page":"1655","volume":"66","author":"Frykberg RG","year":"2002","journal-title":"Am Fam Physician"},{"key":"bibr18-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1999.00410.x"},{"key":"bibr19-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7330.160"},{"key":"bibr20-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61793-6"},{"key":"bibr21-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-005-1054-y"},{"key":"bibr22-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00768.x"},{"key":"bibr23-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01505.x"},{"key":"bibr24-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1002\/j.2055-2335.2006.tb00640.x"},{"key":"bibr25-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.2001.3547"},{"key":"bibr26-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4801.2004.00031.x"},{"key":"bibr27-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.11.1449"},{"key":"bibr28-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67695-7"},{"key":"bibr29-1534734612463935","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.33429"},{"key":"bibr30-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6238"},{"key":"bibr31-1534734612463935","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1754"},{"key":"bibr32-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4863"},{"key":"bibr33-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2010.115"},{"key":"bibr34-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"bibr35-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1002\/stem.420"},{"key":"bibr36-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000299922.96006.24"},{"key":"bibr37-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.22-3-377"},{"key":"bibr38-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00041.x"},{"key":"bibr39-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0226"},{"key":"bibr40-1534734612463935","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2581"},{"key":"bibr41-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.110"},{"key":"bibr42-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100313"},{"key":"bibr43-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00237.x"},{"key":"bibr44-1534734612463935","first-page":"83","volume":"4","author":"Semedo P","year":"2010","journal-title":"Stem Cells"},{"key":"bibr45-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63754-6"},{"key":"bibr46-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3215"},{"key":"bibr47-1534734612463935","first-page":"279","volume":"6","author":"Chao-Fei L","year":"2011","journal-title":"Chin J Inj Repair Wound Healing"},{"key":"bibr48-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35298"},{"key":"bibr49-1534734612463935","doi-asserted-by":"publisher","DOI":"10.3727\/096368910X550198"},{"key":"bibr50-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1161\/hc3501.093817"},{"key":"bibr51-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0216"},{"key":"bibr52-1534734612463935","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002239"},{"key":"bibr53-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0548"},{"key":"bibr54-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1905"},{"key":"bibr55-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0554"},{"key":"bibr56-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0528"},{"key":"bibr57-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1002\/stem.503"},{"key":"bibr58-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0418"},{"key":"bibr59-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-010-9203-9"},{"key":"bibr60-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1038\/nri2395"},{"key":"bibr61-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0878"},{"key":"bibr62-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1559"},{"key":"bibr63-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0008"},{"key":"bibr64-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03422.x"},{"key":"bibr65-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-074997"},{"key":"bibr66-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.11.014"},{"key":"bibr67-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1002\/art.24330"},{"key":"bibr68-1534734612463935","first-page":"1421","volume":"89","author":"Villaron E","year":"2004","journal-title":"Haematologica"},{"key":"bibr69-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1038\/nm1075"},{"key":"bibr70-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.05.002"},{"key":"bibr71-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4349"},{"key":"bibr72-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-011-0114-1"},{"key":"bibr73-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1517\/14712590903039684"},{"key":"bibr74-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.08.004"},{"key":"bibr75-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2010.01122.x"},{"key":"bibr76-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834138100"},{"key":"bibr77-1534734612463935","first-page":"1186","volume":"24","author":"Gang Z","year":"2007","journal-title":"Chin J Exp Surg"},{"key":"bibr78-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-012-0165-2"},{"key":"bibr79-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00029.2004"},{"key":"bibr80-1534734612463935","doi-asserted-by":"publisher","DOI":"10.4161\/org.7.2.15782"},{"key":"bibr81-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0278"},{"key":"bibr82-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-010-9169-x"},{"key":"bibr83-1534734612463935","doi-asserted-by":"publisher","DOI":"10.1021\/mp2001457"},{"key":"bibr84-1534734612463935","first-page":"153","volume":"449","author":"Izadpanah R","year":"2008","journal-title":"Methods Mol Biol"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734612463935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1534734612463935","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734612463935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:07:32Z","timestamp":1777457252000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1534734612463935"}},"subtitle":["Potential Role in Healing Cutaneous Chronic Wounds"],"short-title":[],"issued":{"date-parts":[[2012,10,30]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1177\/1534734612463935"],"URL":"https:\/\/doi.org\/10.1177\/1534734612463935","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,30]]}}}