{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:13:13Z","timestamp":1777713193813,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Chronic skin ulcers require extensive, systemic differential diagnosis; thus, they are difficult to diagnose and treat. Transient or persistent hypercoagulable states are among the rare causes of skin ulcers. Here, we present the case of a 27-year-old woman patient with recurrent, nonhealing skin ulcers of 8 years\u2019 duration, who had been treated unsuccessfully with various medications under different diagnoses at different clinics. On admission, a skin biopsy demonstrated occlusive vasculopathy, and the search for an inherited hypercoagulable state revealed a heterozygous factor V Leiden mutation. The patient was treated with anticoagulants and hyperbaric oxygen. On treatment, the skin lesions healed and did not recur.<\/jats:p>","DOI":"10.1177\/1534734613479379","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T19:29:54Z","timestamp":1362079794000},"page":"35-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Factor V Leiden Mutation\u2013Related Chronic Skin Ulcers"],"prefix":"10.1177","volume":"12","author":[{"given":"Kadir","family":"Kayatas","sequence":"first","affiliation":[{"name":"Haydarpasa Numune Training and Research Hospital, \u00dcsk\u00fcdar, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiz","family":"Cebeci","sequence":"additional","affiliation":[{"name":"Haydarpasa Numune Training and Research Hospital, \u00dcsk\u00fcdar, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cumali","family":"Karatoprak","sequence":"additional","affiliation":[{"name":"Bezmialem Vakif University, Fatih, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet","family":"Benzer","sequence":"additional","affiliation":[{"name":"Yedikule Thoracic Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Refik","family":"Demirtun\u00e7","sequence":"additional","affiliation":[{"name":"Haydarpasa Numune Training and Research Hospital, \u00dcsk\u00fcdar, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuyan","family":"Demirkesen","sequence":"additional","affiliation":[{"name":"Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"bibr1-1534734613479379","first-page":"1644","volume-title":"Braun-Falco\u2019s Dermatology","author":"Sabine AE","year":"2009","edition":"3"},{"key":"bibr2-1534734613479379","first-page":"2121","volume-title":"Williams Hematology","author":"Seligsohn U","year":"2010","edition":"8"},{"key":"bibr3-1534734613479379","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-4-15"},{"key":"bibr4-1534734613479379","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013383"},{"key":"bibr5-1534734613479379","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04001.x"},{"key":"bibr6-1534734613479379","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03026.x"},{"key":"bibr7-1534734613479379","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91803-5"},{"key":"bibr8-1534734613479379","first-page":"9","volume":"26","author":"Akar N","year":"2009","journal-title":"Turk J Hematol"},{"key":"bibr9-1534734613479379","first-page":"217","volume":"34","author":"Dahlback B","year":"1997","journal-title":"Semin Hematol"},{"key":"bibr10-1534734613479379","first-page":"278","volume":"12","author":"Combemale P","year":"2002","journal-title":"Eur J Dermatol"},{"key":"bibr11-1534734613479379","first-page":"477","volume-title":"Thrombosis and Hemorrhage","author":"Bauer KA","year":"2002","edition":"3"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734613479379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1534734613479379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734613479379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:07:35Z","timestamp":1777457255000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1534734613479379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,26]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1177\/1534734613479379"],"URL":"https:\/\/doi.org\/10.1177\/1534734613479379","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,26]]}}}