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It is thought to act by creating a local environment that promotes cell proliferation, angiogenesis, and granulation tissue formation, leading to accelerated wound healing to the point of spontaneous closure or reducing the wound size to facilitate significantly further surgical reconstruction. This case series presents our preliminary experience with the use of a Topical Negative Pressure system in the treatment of challenging ischemic wounds of diabetic patients. It aims to underscore its beneficial effects and explore its potential role in the management of ischemic amputated stumps to avoid ipsilateral re-amputation at a higher level.<\/jats:p>","DOI":"10.1177\/1534734613483769","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T20:31:19Z","timestamp":1368217879000},"page":"138-145","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Current Achievements With Topical Negative Pressure to Improve Wound Healing in Dehiscent Ischemic Stumps of Diabetic Patients"],"prefix":"10.1177","volume":"12","author":[{"given":"Efstratios","family":"Georgakarakos","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, 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