{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:48:28Z","timestamp":1777711708771,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Infection is a major cause of the diabetic foot syndrome being aggravating by the increased burden of multiresistant germs like methicillin-resistant Staphylococcus aureus (MRSA). Maximizing positive outcome for serious MRSA infections requires an aggressive treatment approach and a careful monitoring of the healing process. Therefore, we examined 8 patients with MRSA-infected diabetic foot syndrome Wagner classification grades 2 or 3 (corresponding to the Texas classification stage 2 and 3) during antibiotic treatment with daptomycin. We documented the wound size and obtained samples of wound secretion for analyses of pro-inflammatory interleukin-6 (IL-6), protease (matrix metalloproteinase-9 [MMP-9]), and antiprotease activity (metallopeptidase inhibitor 1 [TIMP-1]). During the course of anti-MRSA therapy, a decrease in the concentration of local IL-6 within the first 3 days followed by a drop of MMP-9 and an increase of TIMP-1 was observed. Finally, a reduction of wound size could be documented. The present data show that efficient antimicrobial treatment with daptomycin leads to a number of beneficial processes at the molecular level of wound healing in MRSA-infected diabetic foot ulcers.<\/jats:p>","DOI":"10.1177\/1534734613490506","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T08:48:41Z","timestamp":1371199721000},"page":"100-105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Daptomycin on Local Interleukin-6, Matrix Metalloproteinase-9, and Metallopeptidase Inhibitor 1 in Patients With MRSA-Infected Diabetic Foot"],"prefix":"10.1177","volume":"12","author":[{"given":"Andreas","family":"Ambrosch","sequence":"first","affiliation":[{"name":"Institute of Laboratory Medicine, Microbiology and Hygiene, Regensburg, Germany"},{"name":"Institute of Laboratory Medicine and Microbiology, Bremerhaven, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Halevy","sequence":"additional","affiliation":[{"name":"Stuttgart-B\u00fcrgerhospital, Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boushra","family":"Fwity","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine and Microbiology, Bremerhaven, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Brin","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine and Microbiology, Bremerhaven, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Lobmann","sequence":"additional","affiliation":[{"name":"Stuttgart-B\u00fcrgerhospital, Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"bibr1-1534734613490506","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1672-5"},{"key":"bibr2-1534734613490506","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008.02.005"},{"key":"bibr3-1534734613490506","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1893-7"},{"key":"bibr4-1534734613490506","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00616-09"},{"key":"bibr5-1534734613490506","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm271"},{"key":"bibr6-1534734613490506","doi-asserted-by":"publisher","DOI":"10.1086\/380449"},{"key":"bibr7-1534734613490506","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl393"},{"key":"bibr8-1534734613490506","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.2.461"},{"key":"bibr9-1534734613490506","doi-asserted-by":"publisher","DOI":"10.1016\/S1067-2516(96)80125-6"},{"key":"bibr10-1534734613490506","unstructured":"German Diabetes Association. 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