{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:13:45Z","timestamp":1777713225465,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,11,9]],"date-time":"2013-11-09T00:00:00Z","timestamp":1383955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Ledderhose disease is disorder of the plantar aponeurosis. This disease is not so common and can be tackled with a surgical or conservative approach. A case of a 73-year-old man came to our attention who had a 26-year history of painless bilateral plantar nodules coalescing into an indurated mass. An ulcerative nodule had been noted in the last 16 months on the right foot, in the absence of trauma, not responsive to conservative treatment, so we decided to perform a biopsy. The histopatologic examination showed squamous cell carcinoma, with warty, well-differentiated, low-grade malignancy. Surgical treatment was suggested, so, in pneumoischemia, we made a surgical incision including the skin lesion. Then we proceeded to sculpture the anterolateral thigh fasciacutaneous flap to obtain adequate soft tissue coverage. The tumor was completely removed. Current reconstructive possibilities comprise a good anatomofunctional recovery even in the case of large demolition requests for the therapy of advanced cases of the disease described in this article. Correlation between Ledderhose disease and the formation of malignant tumors has not been made as yet, but perhaps an element that could unite these pathologies can be researched in the lively cell proliferation that characterizes both. It would be interesting to analyze the biological substrate, as well as the systemic and local levels, in patients where both diseases are manifested.<\/jats:p>","DOI":"10.1177\/1534734613502044","type":"journal-article","created":{"date-parts":[[2013,11,9]],"date-time":"2013-11-09T20:29:58Z","timestamp":1384028998000},"page":"297-300","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Squamous Cell Carcinoma and Ledderhose Disease"],"prefix":"10.1177","volume":"12","author":[{"given":"Alberico","family":"Motolese","sequence":"first","affiliation":[{"name":"University of Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Mola","sequence":"additional","affiliation":[{"name":"University of Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Cherubino","sequence":"additional","affiliation":[{"name":"University of Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micol","family":"Giaccone","sequence":"additional","affiliation":[{"name":"University of Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Pellegatta","sequence":"additional","affiliation":[{"name":"University of Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Valdatta","sequence":"additional","affiliation":[{"name":"University of Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,11,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(84)90002-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(89)90142-2"},{"key":"e_1_3_3_4_2","first-page":"853","article-title":"Uber zerreisungen der plantarfascie","author":"Ledderhose G","year":"1894","unstructured":"Ledderhose G. Uber zerreisungen der plantarfascie. Arch Klin Chir. 1894;853-856.","journal-title":"Arch Klin Chir"},{"key":"e_1_3_3_5_2","first-page":"994","volume-title":"Surgery of the Foot and Ankle","author":"Mann RA","unstructured":"Mann RA, Coughlin MJ. Plantar fibromatosis. In: Surgery of the Foot and Ankle. 6th ed. Vol. 2. St Louis, MO: Mosby-Year Book; 1993:994-995.","edition":"6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199205000-00013"},{"key":"e_1_3_3_7_2","first-page":"364","article-title":"Dupuytren\u2019s disease in the feet causing flexion contractures in the feet","volume":"21","author":"Donato RR","year":"1996","unstructured":"Donato RR, Morisson WA. Dupuytren\u2019s disease in the feet causing flexion contractures in the feet. 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